Oil-in-water type nanometer peonol emulsion oral liquid and its prepn process

An oral emulsion, oil-in-water technology, applied in the field of medicine, can solve the problems of slow disintegration of paeonol sugar-coated tablets after oral administration, low dissolution rate and dissolution rate, affecting the curative effect of paeonol, etc., and improve the sensory quality , Improve storage stability, good solubilization effect

Inactive Publication Date: 2009-08-19
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral disintegration of paeonol sugar-coated tablets is slow, the dissolution rate and dissolution rate are low, and the bioavailability is low. Children, the elderly, bedridden patients or patients with dysphagia are inconvenient to take and poor compliance, which affects the curative effect of paeonol play

Method used

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  • Oil-in-water type nanometer peonol emulsion oral liquid and its prepn process
  • Oil-in-water type nanometer peonol emulsion oral liquid and its prepn process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 3.0g of Tween-80, 1.0g of Span-80, and 1.0g of liquid paraffin, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 20°C, add 0.5g of paeonol directly, and stir Until it is completely dissolved, then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the viscosity of the system is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil type Nanoemulsion, continue to drop and constantly stir, when system suddenly becomes thinner, what produce this moment is stable yellow transparent oil-in-water type paeonol nanoemulsion oral liquid, claims its weight as 10.0g.

Embodiment 2

[0055] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 3.6g of polyoxyethylene hydrogenated castor oil and 0.4g of wheat germ oil, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 24°C, add 0.5g of paeonol directly, and stir until completely dissolved , then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the system viscosity is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanoemulsion. Continue to drop and constantly stir, when the system suddenly becomes thinner, what produce now is the stable colorless transparent oil-in-water type paeonol nanoemulsion oral liquid, claiming that its total weight is 10.1g.

Embodiment 3

[0057] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 3.6g of polyoxyethylene hydrogenated castor oil and 0.4g of olive oil, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 24°C, add 0.1g of paeonol directly, stir until completely dissolved, Then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the viscosity of the system is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanoemulsion. Continue Add dropwise and constantly stir, when the system becomes thinner suddenly, what produce now is the stable colorless transparent oil-in-water type paeonol nanoemulsion oral liquid, claiming that its total weight is 10.0g.

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Abstract

The oil-in-water type nanometer emulsion oral liquid of peonol consists of surfactant, oil, peonol and distilled water. Its preparation process includes the following steps:weighing surfactant with or without co-surfactant; calculating HLB value and selecting oil for reaching emulsifying HLB value near that of the surfactant phase; changing the ratio between the surfactant phase and the oil phase regularly to dissolve peonol in the surfactant; adding distilled water slowly at 20-25 deg.c to form clear and flowing O / W type stable nanometer emulsion oral liquid. The nanometer emulsion oral liquid has high dissolubility of peonol, raised bioavailability of peonol, delayed the time for the medicine to be metabolized in the body, reduced supplementary material amount, low production cost and wide medicine market foreground.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of paeonol medicine, in particular to a transparent and stable oil-in-water paeonol nanoemulsion oral liquid and a preparation method thereof. Background technique [0002] Paeonol (2-hydroxy-4-methoxy-acetophenone) is one of the main active ingredients of Cortex Moutan (Cortex Moutan) and Xu Changqing (Radix Cynanhi Paniculati), which has a wide range of pharmacological activities, including analgesic, Antipyretic, expelling wind, antibacterial and anti-inflammatory, anti-atherosclerosis, inhibiting platelet aggregation, lowering blood pressure, enhancing cellular immune function and anti-oxidation, etc. In recent years, the antitumor effect of paeonol in vivo and in vitro has gradually attracted widespread attention. Paeonol is a fat-soluble drug with a specific odor, slightly spicy, soluble in ethanol and methanol, insoluble in cold water, slightly soluble in hot water,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61K9/107A61K47/44A61P29/00A61P31/04A61P9/10A61P7/02
Inventor 欧阳五庆吴旭锦
Owner NORTHWEST A & F UNIV
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