Oil-in-water type nanometer peonol emulsion oral liquid and its prepn process
An oral emulsion, oil-in-water technology, applied in the field of medicine, can solve the problems of slow disintegration of paeonol sugar-coated tablets after oral administration, low dissolution rate and dissolution rate, affecting the curative effect of paeonol, etc., and improve the sensory quality , Improve storage stability, good solubilization effect
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Embodiment 1
[0053] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 3.0g of Tween-80, 1.0g of Span-80, and 1.0g of liquid paraffin, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 20°C, add 0.5g of paeonol directly, and stir Until it is completely dissolved, then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the viscosity of the system is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil type Nanoemulsion, continue to drop and constantly stir, when system suddenly becomes thinner, what produce this moment is stable yellow transparent oil-in-water type paeonol nanoemulsion oral liquid, claims its weight as 10.0g.
Embodiment 2
[0055] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 3.6g of polyoxyethylene hydrogenated castor oil and 0.4g of wheat germ oil, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 24°C, add 0.5g of paeonol directly, and stir until completely dissolved , then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the system viscosity is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanoemulsion. Continue to drop and constantly stir, when the system suddenly becomes thinner, what produce now is the stable colorless transparent oil-in-water type paeonol nanoemulsion oral liquid, claiming that its total weight is 10.1g.
Embodiment 3
[0057] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 3.6g of polyoxyethylene hydrogenated castor oil and 0.4g of olive oil, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 24°C, add 0.1g of paeonol directly, stir until completely dissolved, Then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the viscosity of the system is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanoemulsion. Continue Add dropwise and constantly stir, when the system becomes thinner suddenly, what produce now is the stable colorless transparent oil-in-water type paeonol nanoemulsion oral liquid, claiming that its total weight is 10.0g.
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