Degradable compound biomaterial membrane for medical purpose

Abstract

As a composite biomedical material and its preparation method, the present invention is suitable for preventing tissue adhesion in medical operations, patching body tissues, etc., and is characterized in that the film is composed of two layers, and one layer as the basic material of the film is made of degradable synthetic high One or both copolymers of molecular polylactic acid and polyglycolic acid are spun by electrospinning technology, so that the film-forming fibers reach the nanometer level and have the excellent characteristics of nano-biological materials, and then coat or spray a One layer of degradable natural polymer chitosan or chitosan derivatives, after post-treatment, to obtain a biodegradable composite biomaterial medical film; at the same time, different amounts of medical plasticizers can be added to the two layers of film to adjust the film Degradation rate to suit different medical requirements. The product has a remarkable anti-adhesion effect, and can also avoid local acid inflammation. At the same time, it has the functions of hemostasis, antibacterial, enhancing body immunity, and accelerating wound healing. It is an ideal biomedical material.

Description

1. Technical field [0001] The invention relates to a degradable composite biomedical film used for preventing tissue adhesion after operation and patching soft tissues of a human body and a preparation method thereof, belonging to the field of surgical medical materials. 2. Background technology [0002] Postoperative adhesion is one of the important problems that have not been well resolved at home and abroad since the history of surgery. With the development of medical technology, a variety of diseases can be completely cured after surgery, but it is easy to adhere between the wound surface and body tissues after surgery. Adhesion formation is characterized by resorption of neutrophils, macrophages, and subsequently fibroblasts, with local production of various cytokines and growth factors. Adhesions can not only cause serious complications, but also the most important reason for significantly increased complications during reoperation. In order to prevent tissue adhesio...

AI Technical Summary

Problems solved by technology

At present, some fluid or semi-fluid anti-adhesion materials such as the polylactic acid anti-adhesion gel produced by Shijiazhuang Ruinuo Biomedical Materials Co., Ltd. and the "Jiantingning" agent produced by Yantai Wanli Medical Products Co., Ltd. are inconvenient to use. Some operations have poor anti-adhesion effects; in some solid diaphragm anti-adhesion materials, such as "Baifeimi" chitosan isolation film produced by Beijing Bailikang Biochemical Co., Ltd., and polylactic acid produced by Chengdu Dikang Zhongke Biomedical Materials Co., Ltd. Some films, etc. degrade too quickly, and some are easy to cause acid accumulation and cause inflammation, and they all lack adhesion to the body, are not easy to fix and difficult to operate, and the products have certain defects and one-sidedness in technology, and the application effect is not very ideal.