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Remedy for glomerular diseae

A technology of glomerulopathy and therapeutic agents, applied in the field of pharmaceuticals for prevention or treatment, can solve problems such as inability to show sufficient effects of nephropathy

Inactive Publication Date: 2007-08-01
KOWA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] However, neither pyridoxamine nor angiotensin II receptor antagonists exhibit a sufficient effect on progressive kidney disease when used alone, and therefore, the development of novel agents that exhibit more excellent effects has been earnestly desired

Method used

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  • Remedy for glomerular diseae
  • Remedy for glomerular diseae

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: Effects on rats with 5 / 6 kidneys removed.

[0044] Under the anesthesia of male SD rats (7 years old, 51 rats, purchased from Japan SLC Co., Ltd.) with pentobarbital, the left kidney was exposed, and the central artery in the branch of the left renal artery was left immobile by using a solid microscope. , the remaining arteries were ligated (usually divided into three branches. In addition, ligation of branch arteries causes ischemia in the innervated area, so the ischemic renal area can be confirmed visually). One week after this, the right kidney was removed (5 / 6 of the kidney removed). Four weeks after the operation, blood was collected from all the rats without anesthesia, and the creatine concentration (Pcr) in plasma was measured. Pcr is a blood parameter serving as an index of renal function, and an increase in Pcr shows a decrease in renal function. For the measurement results of PCR, 36 rats were selected for the experiment except for the specimens...

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Abstract

It is intended to provide a medicinal composition which is efficacious in preventing or treating a glomerular disease, in particular, a progressive chronic glomerular disease. A preventive / remedy for a glomerular disease containing pyridoxamine or its salt and an angiotensin II receptor antagonist.

Description

technical field [0001] The present invention relates to agents useful in the prevention or treatment of glomerulopathy, especially progressive chronic glomerulopathy. Background technique [0002] It is said that there are currently more than 20 million diabetics, suspected diabetics, and potential diabetics in Japan. With the increasing incidence of diabetic nephropathy year by year, among the complications caused by diabetes, the incidence of chronic glomerulonephritis has risen to the first place. [0003] When diabetic nephropathy develops, the biggest problem is that the rate of transition to end-stage renal failure is very high, that is, the rate of transition to dialysis is very high. [0004] Not only diabetic nephropathy, but also chronic glomerulonephritis, when the disease progresses and the patient turns to dialysis, there will be big social problems such as rising medical expenses. For this reason, there is a strong demand for inhibitors or preventive agents a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4415A61K31/4245A61K31/41A61K45/00A61K31/4178A61P13/12A61K31/4184A61P43/00
CPCA61K31/4415A61K31/41A61K31/4245A61K45/06A61K31/4184A61K31/4178A61P13/12A61P43/00A61K45/00
Inventor 中川隆
Owner KOWA CO LTD
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