Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of dendrophenol in preparing medicines for preventing and treating chronic glomerular disease

A technology for glomerular diseases and dendrobium, which is applied in the application field of dendrobium in the preparation of drugs for the prevention and treatment of chronic glomerular diseases, can solve the problems of obvious side effects and limited improvement effect, and achieve the goal of clear ingredients and clear goals Effect

Pending Publication Date: 2019-08-30
HEFEI NORMAL UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The improvement effects of the above drugs are limited, and the side effects are obvious

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of dendrophenol in preparing medicines for preventing and treating chronic glomerular disease
  • Application of dendrophenol in preparing medicines for preventing and treating chronic glomerular disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Improving therapeutic effect of dendrobium phenol on glomerular lesions in methionine model mice.

[0024] Experimental animal: ApoE - / - Mice, 5-7 weeks, male.

[0025] Medicine preparation: select the tablet that dendrobium content is 25mg / sheet and be used for the prevention or treatment of glomerular disease, ultrasonically disperse in 0.5% carboxymethylcellulose sodium (CMC-Na), be used for gavage administration , the dosage is 25mg / kg.

[0026] Experimental instruments: high-speed refrigerated centrifuge, tissue slicer, microplate reader, optical microscope, transmission electron microscope, etc.

[0027] experimental method:

[0028] 1. Grouping and treatment: After adapting to the environment for 1 week, the animals were randomly divided into normal control group, dendrobium control group, model group, and dendrobium group, with 8 animals in each group. All groups were given common feed, the main components of which were protein (24.4%), carbohydr...

Embodiment 2

[0042] According to the conventional preparation method, dendrobium is added into water and an appropriate amount of solubilizer (polyethylene glycol 400) to dissolve, sub-packaged, and sterilized to prepare an oral liquid for prevention or treatment of glomerular diseases with a dendrobium content of 20 mg / ml;

[0043] Dendrobium is prepared according to the conventional preparation method, gelatin and sorbitol are selected as the soft capsule material, and a capsule for the prevention or treatment of glomerular diseases with a content of dendrobium of 20 mg / grain is prepared;

[0044] According to the conventional preparation method, dendrobium was added with excipient cyclodextrin, mixed uniformly, granulated, and tabletted to prepare tablets for the prevention and treatment of glomerular diseases with the content of dendrobium 20 mg / tablet.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of dendrophenol in preparing medicines for preventing and treating chronic glomerular diseases. Animal test results show that the dendrophenol has obvious preventing and improving effects on glomerular function and organic damage of methionine model mice. By utilizing the dendrophenol to be matched with related accessories, health care products or the medicinespreventing and treating the chronic glomerular diseases in a targeted way can be prepared by using a conventional preparation method. The health care products and medicines can be applied to diseasescomprising metabolic syndromes involved in chronic glomerular damage, and the delaying and improvement of progressive course of the glomerular diseases in related diseases.

Description

technical field [0001] The invention relates to an application of dendrobium in the preparation of medicines for preventing and treating chronic glomerular diseases, and relates to a new medical application of dendrobin, an active component of natural plants. Background technique [0002] At present, dendrophenol (dendrophenol, CAS: 108853-14-1), a bibenzyl phenolic substance, is extracted from the root of Dendrobium and is one of the medicinal active ingredients of Dendrobium. At present, some evidence has been found to clarify that Dendrobium has various biological activities, including enhancing the body's immunity, helping the stomach to digest, anti-cataract, regulating blood sugar, and anti-tumor. Through the research on the anti-cataract mechanism of Dendrobium phenol, it is found that Dendrobium phenol can achieve the anti-cataract effect by inhibiting the activity of inducible nitric oxide synthase and its specific binding site. [0003] Chronic kidney disease (CKD...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/09A61P13/12
CPCA61K31/09A61P13/12
Inventor 王伟王香存班恒陈亚军陈静陈金武张雁耿明徐忠东
Owner HEFEI NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com