Glomerulosclerosis markers for chronic glomerular diseases and detection kits of glomerulosclerosis markers

Abstract

The present invention provides glomerulosclerosis markers for chronic glomerular diseases and detection kits of the glomerulosclerosis markers, and relates to the technical field of medicine. The glomerulosclerosis markers for the chronic glomerular diseases are miRNA-196a, miRNA-155, miRNA-490 and interleukin in urine, and the detection kits comprise a kit A and a kit B. An analysis proves that focal segmental glomerulosclerosis (FSGS) is more obvious in renal tubular interstitial injury than other glomerular diseases such as MN and MCD, compared with patients with chronic renal tubular interstitial lesions, interleukin in urine of patients with acute or chronic combined acute renal tubular interstitial lesions is obviously increased. Currently, in many renal tubular functional indexes widely adopted clinically at present, the interleukin in the urine can better reflect the acute renal tubular interstitial lesions, a basis is provided for early and specific clinical discovery of the renal tubular interstitial lesions, and early intervention and treatment of the tubular interstitial injury are one of important links for delaying progression of kidney diseases.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a chronic glomerular disease glomerulosclerosis marker and a detection kit thereof. Background technique [0002] Glomerular diseases are a group of diseases mainly involving bilateral glomeruli with different etiology, pathogenesis, clinical manifestations, pathological changes, disease course and prognosis. It can be divided into primary, secondary and hereditary; primary glomerular disease often has unknown etiology, secondary glomerular disease refers to glomerular damage caused by systemic diseases, hereditary glomerular disease is Genetic. Primary glomerular diseases account for the majority of glomerular diseases and are still the main cause of chronic renal failure in my country. [0003] Focal segmental glomerulosclerosis (FSGS) is one of the common causes of nephrotic syndrome (NS) in adults. Due to its complex etiology and unclear pathogenesis, clinical diagnosis an...

AI Technical Summary

Problems solved by technology

[0003] Focal segmental glomerulosclerosis (FSGS) is one of the common causes of nephrotic syndrome (NS) in adults. Due to its complex etiology and unclear pathogenesis, clinical diagnosis and treatment of FSGS face many difficulties. Interstitial injury is a common feature of various acute and chronic kidney diseases. Currently, urine biomarkers for clinical diagnosis of tubulointerstitial injury mainly include N-acetyl-β-glucosaminidase, urinary retinol-binding protein, Urinary cystatin, etc. However, most of these markers are aimed at the detection of the late stage of the disease, and the predictive effect cannot be achieved. At the same time, although there are many types of detection kits in the prior art, they lack sensitivity and specificity. biomarkers of