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Compound Chinese medicine preparation of breviscapine

A technology of breviscapine and oral preparations, applied in the field of traditional Chinese medicine, can solve the inconvenience of in-depth development of new drug preparations and new dosage forms and the organization of industrialized large-scale production, the lack of targeted treatment of cerebral arteriosclerosis, and the targeted treatment of cardiovascular diseases. It can improve the bioavailability, fast drug absorption and fast drug dissolution.

Inactive Publication Date: 2007-08-15
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation is mainly aimed at the treatment of cerebral arteriosclerosis and the cerebral insufficiency caused by it, cerebral infarction, mental decline, senile dementia and post-stroke limb paralysis, etc. It is not very specific for the treatment of cardiovascular diseases.
And the weak point of this preparation is to use Erigeron breviscapus (Erigeron breviscapus), Ginkgo biloba, Panax notoginseng, Manshanxiang medicinal materials as medicine, adopt the traditional Chinese medicine production method to produce, the raw material that makes has the disadvantages such as high ointment yield, strong hygroscopicity, etc. , it is not convenient for the in-depth development of new drug preparations and new dosage forms and the organization of industrialized mass production
And the patent of notification number CN1058615C can be used for cardiovascular and cerebrovascular diseases and anti-aging etc., but because the prescription of this preparation does not contain Mangospermum or Mangosteen extract, therefore, the weak point of this preparation is the treatment of cerebral arteriosclerosis Not targeted

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Drug ingredients Content per capsule or pill (weight)

[0029] Breviscapine 4 mg

[0030] Panax notoginseng saponins 5 mg

[0031] Ginkgo biloba extract 5mg

[0032] Mangosteen Extract 4 mg

[0033] Macrogol-6000 44mg

[0034] Stearic acid 5mg

[0035] Preparation method: a) Weigh 4 mg of crushed breviscapine, 5 mg of Panax notoginseng saponins, 5 mg of Ginkgo biloba extract, and 4 mg of Mangosteen extract, and mix them evenly; b) Take 44 mg of polyethylene glycol ( 6000), 5 milligrams of stearic acid were melted in a water bath at about 100°C, and the temperature was constant at 65-75°C after melting; c) the above-mentioned medicine was gradually added to polyethylene glycol-6000 and stearic acid constant temperature liquid under stirring, fully Stir to make it evenly mixed, send it to the drug storage tank of the dripping pill machine, keep the temperature at 65-80°C, stir and mix evenly, and then drop it; Simethicone or liquid paraffin is the condensate, and the...

Embodiment 2

[0037] Drug ingredients Content per capsule or pill (weight)

[0038] Breviscapine 1mg

[0039] Panax notoginseng saponins 2mg

[0040] Ginkgo biloba extract 2mg

[0041] Mangosteen Extract 1mg

[0042] Macrogol-6000 24 mg

[0043] Preparation method: a) Weigh 1 mg of crushed breviscapine, 2 mg of Panax notoginseng saponins, 2 mg of Ginkgo biloba extract, 1 mg of Mangosteen extract, and mix well; b) Take 24 mg of polyethylene glycol ( 6000) was melted in a water bath at about 100°C, and the temperature was constant at 65-75°C after melting; c) the above drug was gradually added to the polyethylene glycol-6000 constant temperature liquid under stirring, fully stirred to make it evenly mixed, and sent to the dripping pill In the drug storage tank of the machine; at a constant temperature of 65-80°C, stir and mix evenly before dripping; simethicone or liquid paraffin is the condensate, the liquid temperature of the cooling liquid is 3.5-11°C, and the dripping speed is control...

Embodiment 3

[0045] Drug ingredients Content per capsule or pill (weight)

[0046] Breviscapine 40 mg

[0047] Panax notoginseng saponins 40mg

[0048] Ginkgo Biloba Extract 40mg

[0049] Mangosteen Extract 40mg

[0050] Macrogol-6000 360mg

[0051] Stearic acid 50mg

[0052] Preparation method: a) Weigh 40 mg of pulverized breviscapine, 40 mg of Panax notoginseng saponins, 40 mg of Ginkgo biloba extract, 40 mg of Manshanxiang extract, and mix them evenly; b) Take 360 ​​mg of polyethylene glycol ( 6000), 50 mg of stearic acid were melted in a water bath at about 100°C, and the temperature was kept at 65-75°C after melting; c) the above-mentioned medicine was gradually added to polyethylene glycol-6000 and stearic acid constant temperature solution under stirring, fully Stir to make it evenly mixed, and send it to the drug storage tank of the dripping pill machine; keep the temperature at 65-80°C, stir and mix evenly, and then drop it; simethicone or liquid paraffin is the condensate, ...

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PUM

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Abstract

This invention relates to a Breviscapine compound Chinese medicinal preparation for treating cardio-cerebrovascular diseases. The preparation is prepared from Breviscapine, ginkgo leaf extract, Ginesenoside, schisandra propinqua extract and medicinal auxiliary materials by making into oral preparation including orally disintegrating tablet, dispersible tablet, dripping pill, soft capsule, hard gelatin capsule, and pelletized granule. Product has effects in promoting flow of qi and blood circulation, dissipating blood stasis, and smoothing collaterals, and health protection and theraupetic effect for treating cardio-cerebrovascular disease such as convalescence of apoplexy, coronary heart disease, and angina pectoris, and aneuria and senile dementia.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a compound traditional Chinese medicine oral preparation composed of breviscapine, ginkgo leaf extract, Panax notoginseng saponins, Manshanxiang extract and the like. Background technique [0002] Brevescapin (Brevescapin) is extracted from Erigeron Breviscapus (Vant.) Hand.-Mazz., a composite plant. Its original plant was first recorded in "Southern Yunnan Materia Medica". Erigeron Asarum). Breviscapine is a yellow powder, soluble in alkaline water, slightly soluble in methanol, insoluble in water, chloroform, etc., and has weak acidity. Scutellarin is mainly composed of scutellarin and contains a small amount of scutellarin. Its main component is scutellarin, accounting for about 95%. Its scientific name is 4′,5,6-trihydroxyflavone -7-glucuronide. Pharmacological studies have proved that breviscapine can dilate cerebral blood vessels, reduce cerebral va...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61K9/16A61K9/20A61K9/48A61P9/10A61K31/704A61K31/7048
Inventor 丁江生张国丽高宏涛
Owner KPC PHARM INC
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