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Oral medicine composition containing salvianolic acid and its prepn

A technology of salvianolic acid and its composition, which is applied in the field of oral pharmaceutical composition containing salvianolic acid A and its preparation, and can solve problems such as the inability to obtain batch-grade salvianolic acid A

Inactive Publication Date: 2012-02-01
PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] After reviewing the literature and patents, there is no report on the compatibility of salvianolic acid A and breviscapine, but there is a report on the compatibility of salvianolic acid A and breviscapine. Although this drug combination has a certain curative effect, due to the existence of the existing technology There is a certain defect: the salvianolic acid obtained is mainly salvianolic acid B, and the batch-grade salvianolic acid A cannot be obtained. Therefore, the batch-grade salvianolic acid A and brevis Whether the flower elements can be combined requires researchers to go through a large number of scientific research experiments to determine

Method used

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  • Oral medicine composition containing salvianolic acid and its prepn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0211] Preparation of salvianolic acid A:

[0212] Salvia miltiorrhiza was extracted with 85% ethanol solution to obtain an alcohol extract, the alcohol extract was concentrated with ethanol until it was exhausted, the pH value was adjusted to 9.0, the temperature was 80°C, and heated for 6 hours, the solution was filtered, and the filtrate was separated by HPD-400 macroporous resin column chromatography , first eluted with water and 30% dilute ethanol to remove impurities, then eluted with 70% ethanol, collected the eluate, concentrated, and dried to obtain salvianolic acid A, the content of which was 59.3%.

[0213] or

[0214] Salvia miltiorrhiza was extracted with water to obtain the water extract, adjust the pH value to 3.5, temperature of 110°C, gauge pressure of 0.05MPa, and heat for 6 hours; the solution was filtered, and the filtrate was separated by HPD-400A macroporous resin column chromatography, firstly water, 30% Elute with dilute ethanol to remove impurities, ...

Embodiment 2

[0237] Preparation of salvianolic acid A:

[0238] Salvia miltiorrhiza was extracted with water to obtain the water extract, adjust the pH value to 7.5, and heat at 30°C for 1 hour. The solution was filtered, and the filtrate was separated by HPD-100 macroporous resin column chromatography, firstly eluted with water and 10% dilute ethanol, and removed Impurities were then eluted with 30% ethanol, and the eluate was collected, concentrated, and dried to obtain salvianolic acid A. The content of salvianolic acid A is 50.1%.

[0239] or

[0240] Extract the salvia miltiorrhiza with 20% ethanol solution to obtain the alcohol extract, concentrate the ethanol to the utmost, adjust the pH value to 9.0, heat at 80°C for 6 hours, filter the solution, and separate the filtrate by HPD-100A macroporous resin column chromatography , first eluted with water and 30% dilute ethanol to remove impurities, then eluted with 70% ethanol, collected the eluate, and recovered the ethanol to the utmos...

Embodiment 3

[0263] Preparation of salvianolic acid A:

[0264] Extract Salvia miltiorrhiza with 70% ethanol solution to obtain alcohol extract, concentrate the ethanol to the maximum, adjust the pH value to 4.5, 120°C temperature, gauge pressure 0.10MPa, and heat for 4 hours; the solution is filtered, and the filtrate is passed through HPD-450 Pore ​​resin column chromatography separation, first eluted with water and 20% dilute ethanol to remove impurities, then eluted with 50% ethanol, collected the eluate, concentrated, and dried to obtain salvianolic acid A with a content of 55.1% .

[0265] or

[0266] Extract the salvia miltiorrhiza with 60% ethanol solution to obtain the alcohol extract, concentrate the ethanol to the maximum, adjust the pH value to 4.0, 125°C temperature, and a gauge pressure of 0.14MPa, and heat for 2 hours; the solution is filtered, and the filtrate is passed through D101 macroporous resin Column chromatography separation, first eluted with water and 15% dilut...

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Abstract

The present invention discloses one kind of oral medicine composition containing red sage salvianolic acid and its preparation process. The oral medicine composition has the composition determined through pharmacodynamic experiment, pharmacokinetic experiment and toxicologic experiment as red sage salvianolic acid 1-10 weight portions and breviscapine 1-20 weight portions, preferably red sage salvianolic acid 1-5 weight portions and breviscapine 1-5 weight portions. The present invention also discloses the detection and analysis method and the use of the medicine composition. Pharmacologic experiment shows its excellent pharmacologic effect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to an oral pharmaceutical composition containing salvianolic acid A and a preparation method thereof. Background technique [0002] Salvianolic acid A is the most active ingredient in Salvia miltiorrhiza, and has good pharmacological effects (Du Guanhua [Basic Medicine and Clinic, 2000, 20(5): 10-14], Hu Yiyang [Acta Pharmacology of Traditional Chinese Medicine, 1997, 18(5): 478-480]), the content of salvianolic acid A in Salvia miltiorrhiza is very low, only about 5 / 10,000, even if it is extracted through a series of processes, only trace amounts of salvianolic acid A can be obtained Phenolic acid A. Therefore, traditional Chinese medicine uses Danshen to participate in the compatibility of other medicinal materials. The essence is the compatibility with other relatively weak components of Danshen (such as tanshinone, salvianolic acid B, etc.). Therap...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/7048A61K31/216A61P9/00A61P3/06A61P1/16A61P19/06A61P35/00A61K36/185
Inventor 顾群李志刚渠守峰米长江栗艳彬林治荣鄯慧珍
Owner PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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