Method for constructing complicated Nano form by suing DNA molecule

A DNA molecule and nanotechnology, applied in recombinant DNA technology, DNA/RNA fragments, sugar derivatives, etc., can solve the problems of restricting the use of complex nanoshapes, and no research reports on the construction of asymmetric nanoshapes, etc., to achieve simple operation. The effect of feasible and broad development prospects

Inactive Publication Date: 2007-10-10
SHANGHAI JIAO TONG UNIV
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Problems solved by technology

However, these nano-shapes are all symmetrical figures, and these nano-shapes have not been converted into other materials such as metals after self-assembly of DNA, and have not been transferred from solution to air, which greatly limits the complexity. Uses of nanoshapes in areas such as electronics manufacturing
[0004] After searching the domestic and foreign literature of ...

Method used

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  • Method for constructing complicated Nano form by suing DNA molecule
  • Method for constructing complicated Nano form by suing DNA molecule
  • Method for constructing complicated Nano form by suing DNA molecule

Examples

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Embodiment 1

[0022] In this embodiment, DNA molecules are used to construct a nanoscale imitation map of China. The basic design idea is to use a long DNA single strand (called scaffolding strand) to fold into the shape of a map of China, and then use several short DNA single strands (called staple strands) to fix it by complementing the scaffolding strand the shape.

[0023] Step 1: Draw a line graph representing the scaffolding chain according to the outline of the map of China.

[0024] M13mp18 DNA was selected as the scaffolding chain, and the scaffolding chain was repeatedly folded horizontally to fill the outline of the Chinese map shape for the shape of the Chinese map. As shown in Figure 1, the main part of the map of China is vertically divided into east and west regions based on the center of Hainan Island, and the northeast part and northwest part are also vertically divided into two regions. As a starting point, fold horizontally from south to north to complete the area on th...

Embodiment 2

[0040] In this embodiment, DNA molecules are used to construct nanoscale inductor shapes, and DNA nanostructures are metallized with silver in solution and transferred to air to construct nanoscale silver inductors.

[0041] Step 1: Draw a line graph representing the scaffolding chain based on the outline of the inductor.

[0042] Using a method completely similar to step 1 in Example 1, select M13mp18 DNA as the scaffold chain, and for the inductor shape, fold the scaffold chain repeatedly in the horizontal direction to fill the outline of the inductor shape, and obtain the scaffold as shown in Figure 4 The broken line graph of the chain, the length of each horizontal line segment on the broken line graph corresponds to the number of bases on each segment of the scaffold chain after folding.

[0043] Step 2: Program the sequence of staple chains.

[0044] With a method completely similar to step 2 in Example 1, according to the sequence of the scaffold chain and the obtained...

Embodiment 3

[0052] In this embodiment, DNA molecules are used to construct a nanoscale inductor shape, and the DNA nanostructure is metallized with copper in a solution and transferred to air to construct a nanoscale copper inductor.

[0053] Step 1: Draw a line graph representing the scaffolding chain based on the outline of the inductor.

[0054] Using a method completely similar to step 1 in Example 1, select M13mp18 DNA as the scaffold chain, and for the inductor shape, fold the scaffold chain repeatedly in the horizontal direction to fill the outline of the inductor shape, and obtain the scaffold as shown in Figure 4 The broken line graph of the chain, the length of each horizontal line segment on the broken line graph corresponds to the number of bases on each segment of the scaffold chain after folding.

[0055] Step 2: Program the sequence of staple chains.

[0056]With a method completely similar to step 2 in Example 1, according to the sequence of the scaffold chain and the obt...

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Abstract

This invention relates to a method for constructing complex nanostructure with DNA molecules. The method comprises: selecting a single-stranded DNA as a scaffold chain, horizontally folding the DNA to obtain targeted structure, designing several short single-stranded DNAs as staple chains according to the folded scaffold chain, mixing the staple chains and the scaffold chain in solution, annealing, and self-assembling to obtain the target structure. This invention also discloses a method for metallization of DNA nanostructure with electronic device shape in the solution, and transferring it into air to obtain nanoscale electronic device. The method has such advantages as easy operation, and can construct symmetric or asymmetric highly complex DNA nanostructure that can be used in electronic industry.

Description

technical field [0001] The invention relates to a method for constructing complex nano-shapes (two-dimensional symmetric nanostructures, two-dimensional asymmetric nanostructures) with DNA molecules, and further transforming the complex nano-shapes of DNA in a solution into other materials such as metals and transferring them to the air Therefore, the application of the method in the manufacture of electronic devices and the like is realized. The invention belongs to the field of graphic processing of nanotechnology. Background technique [0002] Compared with the traditional top-down shape construction method, the bottom-up self-assembly method is undoubtedly an important new structure (especially nanoscale structure) fabrication method. The knowledge and technology accumulation of DNA and the coding ability of DNA itself make the DNA-based self-assembly construction method the most potential self-assembly method. [0003] The research results of using DNA self-assembly t...

Claims

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Application Information

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IPC IPC(8): C07H21/04C12N15/11
Inventor 贺林钱璐璐樊春海张亚非胡钧汪颖王英赵健
Owner SHANGHAI JIAO TONG UNIV
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