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Intraoral disintegration type solid preparation containing povidone iodine

A technology for solid preparations and povidone-iodine, which is applied in the direction of medical preparations containing active ingredients, medical preparations with inactive ingredients, and pill delivery, which can solve liquid leakage, uniform povidone-iodine content, and povidone-iodine low iodine content

Inactive Publication Date: 2007-12-19
KOWA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this formulation has a problem of poor portability and leakage of liquid from the container due to its bulky container
In addition, since this spray is sprayed directly to the pharynx, it can only sterilize the throat. In order to sterilize the mouth, it is necessary to use a cough agent, so it is not convenient.
[0004] If it is possible to provide an orally disintegrating solid preparation containing povidone-iodine, although there is the possibility of solving the above-mentioned problems, because the povidone-iodine content per unit of solid preparation is very small (it is desirable to provide 300~1,000 per unit weight mg tablet contains about 5 mg of povidone-iodine solid preparation), so there is a problem that it is difficult to make the content of povidone-iodine uniform

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Mix 10g povidone-iodine (Nippon Pharmacopovidone-iodine, BASF Japanese company production), 40g carboxymethylcellulose (NS-300, NICHIRIN chemical industry company production), 8g aspartame (aspartame , produced by Ajinomoto Co.), 726g D-sorbitol (NEOSORBP60W, produced by Roquette Company), 8g 20% ​​L-menthol powder, 8g sodium stearate fumarate (Pruv, produced by Kimura Sangyo Co., Ltd.), using pressed The tablet machine makes 1 tablet of 400 mg lozenges. The tablet hardness was 104N.

[0027] It should be noted that the above-mentioned 20% L-menthol powder refers to mixing L-menthol (l-menthol, produced by Takasago Fragrance Industry Co., Ltd.) and hydrous silicon dioxide (Adosolider 102, Freund Industrial Co., Ltd.) in a ratio of 1:4. Company production), the following examples and comparative examples are also the same.

Embodiment 2

[0029] Mix 10g povidone-iodine (Nippon Pharmacopovidone-iodine, produced by BASF Japan Co.), 60g carboxymethylcellulose (NS-300, produced by NICHIRIN Chemical Industry Co., Ltd.), 16g acesulfame potassium (Sunett, Nutrinova company) production), 698g D-sorbitol (NEOSORB P60W, produced by Roquette), 8g 20% ​​L-menthol powder, 8g magnesium stearate (magnesium stearate, produced by Taiping Chemical Industry Co., Ltd.), manufactured using a tablet press 1 lozenge of 400 mg. The tablet hardness was 118N.

manufacture example 1

[0036] Manufacturing example 1: Determination of available iodine content

[0037] For each of the solid preparations of Examples and Comparative Examples, the available iodine content was measured immediately after manufacture and stored at 60° C. for 1 week (packaged in a sealed bottle) by neutralization titration using a sodium thiosulfate solution, and the remaining rate was calculated. . The results are shown in Table 1.

[0038] Table 1

[0039] Example

1

Example

2

comparative example

1

comparative example

2

comparative example

3

Povidone iodine

5

5

5

5

5

carboxymethyl cellulose

20

30

-

20

20

Croscarmellose Sodium

-

-

20

-

-

aspartame

4

-

4

4

4

Acesulfame Potassium

-

8

-

-

-

...

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Abstract

An intraoral disintegration type solid preparation containing povidone iodine as an active ingredient that can be obtained by direct powder tableting of a mixture containing granular sugar alcohol and povidone iodine (provided that the mixture is one containing none of basic ingredients and not having undergone any wet granulation), and that is uniform in the content of povidone iodine per one-unit solid preparation, being a high-quality solid preparation sustaining iodine stability.

Description

technical field [0001] The invention relates to an orally disintegrating solid preparation containing povidone-iodine. Background technique [0002] Povidone-iodine: The Merck Index 13 th edition, 2001) is a compound of polyvinylpyrrolidone and iodine, which is a 1-vinyl-2-pyrrolidone polymer, and is widely used as a safe drug with bactericidal effect in bedsore treatment, finger disinfection, or oral and For pharyngeal sterilization, etc. As povidone-iodine for oral cavity and pharynx sterilization, a cough solution diluted in water is generally used, but this preparation has a disadvantage of being troublesome to handle because it requires dilution of the drug when used. [0003] As a formulation that overcomes this disadvantage, there is provided a spray in which povidone-iodine is dissolved in water and glycerin, and an appropriate sweetener, flavoring, etc. are added. However, this preparation has a problem of being poor in portability due to its bulky container and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/79A61K47/42A61K9/26A61P1/02A61K33/18A61P17/02A61K47/10A61P31/02A61K47/36
CPCA61K31/79A61K33/18A61K9/0056A61P1/02A61P17/02A61P31/02A61K2300/00A61K9/20A61K47/42
Inventor 狩野祐一郎久我宏彰前谷茂宏
Owner KOWA CO LTD
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