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Uncoupling protein gene of lamprey and application

A technology for uncoupling proteins and lampreys, which can be used in applications, gene therapy, genetic engineering, etc., and can solve problems such as functional disputes

Inactive Publication Date: 2007-12-26
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, their function is still debated

Method used

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Examples

Experimental program
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Effect test

Embodiment

[0062] 1. Lamprey tissue sampling

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Abstract

This invention relates to molecular cloning of uncoupling protein (UCP) of Lampetra japonica. The UCP gene is cloned from Lampetra japonica with degenerate primer through 3',5'-RACE. UCP gene is associated with serveral diseases, such as diabetes mellitus, cardiovascular diseases and tumors. UCP gene can be used as a drug target for manufacturing drugs for treating above diseases.

Description

1. Technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to molecular cloning of lamprey uncoupling protein (uncoupling protein, UCP). 2. Background technology [0002] The main function of mitochondria is to participate in energy metabolism. When mitochondria respire, the respiratory chain transfers electrons and pumps protons from the mitochondrial matrix to the membrane space, forming the mitochondrial transmembrane potential. Protons return to the mitochondrial matrix by driving ATP synthase to synthesize ATP, forming a coupling of oxidation and phosphorylation. UCP localized in the mitochondrial inner membrane can leak protons from the mitochondrial intermembrane space back into the matrix, thereby reducing the membrane potential of mitochondria and uncoupling oxidation and phosphorylation. A total of 5 UCP family members have been found so far. Since UCP4 and UCP5 are far from the homology of the other 3 members, whethe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/12A61K48/00A61P3/10A61P9/00A61P35/00
Inventor 孙国勋陈坤张辰宇项阳王修强陈均远张俊峰张红杰徐威邹季虹
Owner NANJING UNIV
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