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Pharmaceutical composition of cyclodextrin dragon's blood and method of preparing the same

A technology of cyclodextrin and composition, which is applied in the field of pharmaceutical composition for cyclodextrin inclusion of insoluble traditional Chinese medicine Dracula, can solve the problems of unfavorable inclusion compound formation and the like, and achieve the effect of improving pharmacy performance

Inactive Publication Date: 2010-08-25
NANJING NORMAL UNIVERSITY +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although ethanol can increase the water solubility of dried blood, it will compete with dried blood for cyclodextrin when forming inclusion complexes, which is not conducive to the formation of inclusion complexes

Method used

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  • Pharmaceutical composition of cyclodextrin dragon's blood and method of preparing the same
  • Pharmaceutical composition of cyclodextrin dragon's blood and method of preparing the same
  • Pharmaceutical composition of cyclodextrin dragon's blood and method of preparing the same

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Abstract

The invention relates to a drug combination containing cyclodextrin and dracorhodin inclusion complex, which comprises the cyclodextrin and the dracorhodin. The invention is characterized in that: the weight ratio of the two materials is 1:1 to 1:100. The dracorhodin refers to the resin abstracted from the lipid containing trees of the Dranaena cochinchinensis(Lour.)S.C.Chen. The cyclodextrin refers to the mixture of arbitrary two or three kinds of the following materials: Beta-cyclodextrin, hydroxypropyl - Beta -cyclodextrin, methyl butyl - Beta -cyclodextrin. The invention can produce dracorhodin-cyclodextrin inclusion complex without any organic solvent impurities. Being able to significantly improve the pharmaceutical properties of the dracorhodin and enhance the activity, the cycldextrin inclusion complex has significance and great economic value for the development and preparation of the high effective low toxic dracorhodin.

Description

Technical field The invention relates to a pharmaceutical composition containing cyclodextrin and insoluble traditional Chinese medicine Dragon's blood and a preparation method thereof. Background technique Dragon Blood (Resina Draconis; Dragon Blood) is also abbreviated as Dragon Blood, which is a resin obtained by extracting the fat-containing wood of the Liliaceae plant Dranaena cochinchinensis (Lour.) S.C. Chen. In the 1970s, Chinese botanists discovered that Guangxi had abundant dracaena plant resources. In 1990, it was approved by the Ministry of Health for trial production as "Guangxi Dragon Blood". It was officially produced in 1995 and the drug standard implemented in 1999 was named " "Draconis" (standard number WS3—082(Z-016)—99(Z)) is one of the famous southern medicines. It tastes sweet, salty, and calm; Guixin, liver, and kidney meridian; has blood stasis to relieve pain, hemostasis, and muscle growth The effect of restraining sore. It is mainly used for traumati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/40A61K36/896A61P9/10A61P3/10A61P1/00A61P17/00A61P35/00A61K135/00
Inventor 任勇宁劝奎韩彬彬徐云峰汪伯良
Owner NANJING NORMAL UNIVERSITY