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Application of porphyrin class in preparation of sound motivation therapy medicine and sound motivation therapy

A technology of sonodynamic therapy and porphyrin compounds, applied in the application of porphyrins in the preparation of sonodynamic therapy drugs and the field of sonodynamic therapy, can solve photodermatitis, limited penetration depth of red light, and increase patient pain and danger And other issues

Active Publication Date: 2008-04-09
GUANGZHOU YISI BIOENG TECH
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  • Abstract
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AI Technical Summary

Problems solved by technology

However, photodynamic therapy has three major weaknesses: First, the effective penetration depth of red light to the human body is limited, less than 10mm, and it can only treat very few very superficial or limited tumors
The second is that the excretion speed of existing photosensitizers in normal cells is very slow. After treatment, patients should avoid light for 30 days, otherwise it will cause photodermatitis
Third, photodynamic therapy often requires interventional methods to introduce optical fibers into the body or inside the tumor, which increases the pain and danger of the patient
However, as far as sonodynamic therapy is concerned, there is no ideal sound-sensitive substance and suitable method for clinical treatment.

Method used

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  • Application of porphyrin class in preparation of sound motivation therapy medicine and sound motivation therapy
  • Application of porphyrin class in preparation of sound motivation therapy medicine and sound motivation therapy
  • Application of porphyrin class in preparation of sound motivation therapy medicine and sound motivation therapy

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Experimental program
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Embodiment

[0088] 1. Animal test A

[0089] 1. Experimental materials and methods

[0090] 1.1 Sound sensitizer: The sound sensitizer is chlorin e4, obtained according to the method of Chinese patent 99119878.6. Dissolve with water for injection protected from light to make the final concentration 4mg / mL, and store at 4°C protected from light and sound.

[0091] 1.2 Tumor strain and experimental animals: S-180 sarcoma cell line was purchased from Zhongshan Medical University Cancer Hospital. Pure-line KM mice (female, weighing 18-20 g / only) used in the experiment were provided by the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine, and were fed and tested according to routine. The tumor cell lines were passaged three times in the peritoneal cavity of KM mice, and the stable growth of the cell lines was proved to be used in this experiment. The KM mouse S180 sarcoma model is one of the animal tumor models designated by the National Tumor Drug Trial. ...

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Abstract

The invention provides the application of porphyrin chemical compound which is in one of the right formulas in preparing a drug of acoustodynamic therapy and the acoustodynamic therapy. The acoustodynamic therapy includes the steps that the porphyrin chemical compound is applied to a patient, and then acoustic wave acts on the patient, wherein, the meaning of each symbol is as stated in the instruction.

Description

technical field [0001] The invention relates to the application of porphyrin compounds in the preparation of sonodynamic therapy (Sonodynamic Therapy, SDT for short) medicine and the sonodynamic therapy. Background technique [0002] Malignant tumor is the number one killer affecting human health in the 21st century. Currently, photodynamic therapy (Photodynamic Therapy, PDT) and sonodynamic therapy have good application prospects as malignant tumor treatment methods with good selectivity and few side effects. [0003] Photodynamic therapy is carried out in two steps: the patient first injects or takes a photosensitive substance orally, and then irradiates it with light of a certain wavelength to activate the photosensitive substance and generate "singlet oxygen", thereby killing abnormal cells and microorganisms. Because photosensitive substances can specifically accumulate in cancer cells and other abnormal cells, this method only kills abnormal cells without damaging nor...

Claims

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Application Information

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IPC IPC(8): A61K31/409A61P35/00
Inventor 王晓怀苏江安李青赵广连罗一帆于波
Owner GUANGZHOU YISI BIOENG TECH
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