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Hair and/or scalp care compositions incorporating terpenoid compounds

A technology of terpenoids and scalp care, applied in the treatment and/or prevention of inflammatory skin conditions such as dandruff and dandruff exfoliation, treatment and/or prevention of inflammatory skin conditions such as scalp itching and dandruff exfoliation , can solve problems such as unclear

Inactive Publication Date: 2008-05-07
UNILEVER NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is not clear why some people have the condition and others do not

Method used

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  • Hair and/or scalp care compositions incorporating terpenoid compounds
  • Hair and/or scalp care compositions incorporating terpenoid compounds
  • Hair and/or scalp care compositions incorporating terpenoid compounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0125] Terpenoids of formula (I), (II) or (III) above were evaluated for their ability to activate cannabinoid receptor 1 (CB1R) and cannabinoid receptor 2 (CB2R). The ClogP value was also determined.

[0126] As described by the manufacturer (Perkin-Elmer) and using [3H]CP-55,490 as radioligand, using recombinant CB obtained from overexpressing human 1 The membranes of HEK293 cells were subjected to CB1R experiments.

[0127] As described by the manufacturer (Perkin-Elmer) and using [3H]CP-55,495 as radioligand, using recombinant CB obtained from overexpressing human 2 The membranes of HEK293 cells were subjected to CB2R experiments.

[0128] Active compound data with K i (mM) represents the mean ± SEM of n = 3 determinations.

[0129] Values ​​commented (for each compound) are EC50 values. Defined as the molar concentration of agonist that produces 50% of the maximum possible response to that agonist. The value is reported in micromoles.

[0130] The absence of values...

Embodiment 4

[0135] Below is an embodiment of the shampoo composition of the present invention:

[0136] components

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Abstract

The present invention provides a hair and / or scalp care composition comprising a terpenoid compound of formula (I), (II) or (III) in which R1 to R11 are each, independently, -H,-F,-Cl,-Br,-I,-OH, lower alkyl (e.g. C1-6 alkyl) or lower alkoxy (e.g. C1-6 alkoxy).

Description

[0001] The present invention relates to hair and / or scalp care compositions incorporating certain optional terpenoids. The present invention also relates to the use of these terpenoids for the treatment and / or prevention of inflammatory skin conditions such as scalp itching and dandruff. Background of the invention [0002] Malassezia yeasts such as Malassezia furfur are generally believed to be the main cause of dandruff. However, it is not clear why some people have the condition and others do not. Increasing levels of Malassezia on the scalp is known not to automatically cause dandruff. This suggests that Malassezia is necessary but not sufficient to cause the condition. [0003] Recent studies have shown that dandruff is associated with changes in scalp conditions. It has been shown that dandruffing scalp stratum corneum lipids such as ceramides are reduced, sensitive to topical histamine and perturbed balance of inflammatory cytokine marker levels in the stratum corneu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61Q5/00A61K8/49
CPCA61K8/498A61Q5/006A61P17/00A61P17/04A61P17/16A61P29/00A61P31/10A61K8/49A61Q5/00
Inventor R·博加尔J·丘夫H·梅尔德伦
Owner UNILEVER NV