Intermediate compound of a traditional Chinese medicinal preparation and preparation method and application thereof

A technology of traditional Chinese medicine preparations and intermediates, which is applied in the field of traditional Chinese medicine and can solve problems such as damage, inappropriate animal medicinal materials, and loss of active ingredients

Inactive Publication Date: 2008-05-28
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The active ingredients of leeches are not clear, and the literature reports that proteins, polypeptides, trace elements, etc. are the active ingredients. The ambiguity of the active ingredients is an inherent problem of animal medicinal materials. Traditional extraction and concentration methods are used to

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0128] Get the leech medicinal material, wash, dry at low temperature, weigh 167g, pulverize with a common pulverizer and pass through a 40-mesh sieve, add 23g of starch, superfine pulverize with a vibrating mill for 20 minutes, then add micronized silica gel 10g, continue superfine pulverization for 10 minutes Minutes to prepare an ultrafine mixture with a central particle diameter of less than 25 μm, which is granulated and filled into capsules.

Embodiment 2

[0130] Take the leech medicinal material, wash it, dry it at low temperature, weigh 200g, grind it through a 40-mesh sieve with an ordinary pulverizer, add 20g of cyclodextrin and 10g of micropowder silica gel, and ultrafine pulverize it with a vibrating mill for 30 minutes to obtain the centriole The ultrafine mixture with a diameter of less than 25 μm is granulated and compressed into tablets.

Embodiment 3

[0132] Get the leech medicinal material, wash it, dry it at low temperature, weigh 167g, pulverize it through a 40-mesh sieve with an ordinary pulverizer, double cyclodextrin 63g, pulverize it with a vibrating mill for 40 minutes, then add 20g of micropowder silica gel, continue to superfine Finely pulverize for 10 minutes to prepare an ultrafine mixture with a central particle diameter of less than 25 μm.

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PUM

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Abstract

The invention discloses an intermediate of a liquid Chinese medicine preparation, the preparation and the application thereof, the invention includes pulverization method of single leech ultrafine powder, in particular to a pulverization method of preparing leech ultrafine powder by wet-method ultrafine pulverization method. The method is that leech medical material is pulverized through a traditional method, then added with any one or the compositions of a plurality of gum acacia, betadex, starch and solid carbowax with proper quantity, and then undergone ultrafine pulverization to obtain the preparation intermediate; the intermediate products can be prepared into required dosage forms. This method can improve pulverization efficiency and decrease raw material usage amount in the products.

Description

technical field [0001] The invention relates to an intermediate of a leech-containing single medicinal material preparation and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] 1. Research progress of leeches [0003] The effect of leech is to break blood, expel blood stasis, and eliminate symptoms. It can be used for lumps in the abdomen, blood stasis, amenorrhea, bruises, thrombocytosis, and cerebral hemorrhage. Leeches were first recorded in "Shen Nong's Materia Medica": "The main purpose is to drive away bad blood, blood stasis, moon closure, accumulation of broken blood, no children, and water passages." Salty and bitter, in order to remove blood accumulation, it is the medicine of the liver meridian blood, so it can dredge the liver meridian and gather blood." [0004] The curative effect of leeches is definite, and it has extremely high medicinal value and economic value. Its pharmacological effect...

Claims

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Application Information

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IPC IPC(8): A61K35/62A61K9/14A61K9/16A61K9/20A61K9/48A61P3/06A61P9/00A61P15/00A61P19/00A61P29/00
Inventor 周小明刘国飞
Owner 北京凯瑞创新医药科技有限公司
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