Propofol vein mixing injection and preparing method thereof

Abstract

Disclosed are propofol vein mixed injection and preparation method of the propofol vein mixed injection. The raw material and ratio are as following: propofol : fentanyl : soybean oil : refined lecithin : glycerol : water equal to 2 : 0.003 : 15 : 1 : 2 : 35. The preparation method is as flowing: (1) the soybean oil and the lecithin are heated and mixed evenly to be made into oil phase; (2) the propofol is added into the oil phase, and then mixed solution can be obtained; (3) the glycerol is added into water for injection, mixed evenly and filtered to be made into water phase; (4) the mixed solution obtained in step (2) is poured into the water phase obtained in step (3), and then colostrum is made, and the pH value is 7.35 to 7.85; (5) the made colostrum is homogenized under high pressure; (6) the emulsion of the colostrum is filtered, and then is filled in the ampoule of 10 ml, over flowed by nitrogen normally and melt sealed; (7) the bacteria are killed. The invention is applied to painless gastroscopy in clinics, and then the invention plays the role of analgesia as well as sedation, reduces stimulation of the gastroscopy on the patients, improves the clinic visiting and return visiting efficiency of gastroscopy patients and widens the age limit of the clinic visiting patients.

Description

technical field [0001] The invention relates to an intravenous injection, in particular to a propofol mixed intravenous injection prepared with propofol, an analgesic intravenous anesthetic, as a main component, and also relates to a preparation method of the preparation. Background technique [0002] Painless gastroscopy is a new concept and new technology developed in some regions at home and abroad in recent years, and it has attracted more and more attention. For a long time, traditional gastroscopy is only performed under throat anesthesia. Patients often have to endure the pain of throat discomfort and severe nausea and vomiting caused by insertion of the endoscope. In clinical practice, patients often refuse to accept gastroscopy due to fear. Many patients with stomach problems cannot get a clear diagnosis and treatment. The emergence of painless gastroscopy technology fundamentally solves the pain caused by gastroscopy to patients, enabling patients to complete the ...

AI Technical Summary

Problems solved by technology

At the same time, some oral analgesic preparations also play a good role in painless gastroscopy, but oral analgesics are slow to take effect, and drug residues tend to remain on the surface of the gastric mucosa, which affects the accurate judgment of the gastroscopy doctor on the lesion. It interferes with the test results, and patients often have adverse reactions such as nausea and vomiting after the test