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Compound sulfamonomethoxine daimeton injection and preparing method thereof

A technology of sulfamethoxine and metmethoxine, which is applied in the field of compound sulfamethoxine injection and its preparation, can solve the problem of hindering the metabolism and utilization of folic acid of sensitive bacteria, the inability to reduce dihydrofolate, and hindering the synthesis of bacterial nucleic acid and other problems, to achieve rapid drug absorption, safe curative effect, and good effect of use

Inactive Publication Date: 2008-06-18
浙江道格凯特实业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Trimethoprim (TMP) can inhibit dihydrofolate reductase, so that dihydrofolate cannot be reduced to tetrahydrofolate, thus hindering the metabolism and utilization of folic acid in sensitive bacteria, thereby hindering the synthesis of bacterial nucleic acid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A preparation method of compound sulfamethoxine injection, comprising the steps of:

[0041] (1). Weigh 70ml of α-pyrrolidone and heat to 80°C; (2). Add 2g of TMP, 10g of sulfamethoxine, 5g of deoxyoxytetracycline, stir and dissolve to form solution A; (3). Add 0.1 g of sodium metabisulfite to water for injection, stir and dissolve to form solution B; (4). Pour solution B into solution A, and then heat to dissolve until clear to form a clear solution; (5). Use HCL or ethanolamine to adjust the pH of the clear liquid to 8.5, then add water for injection to make the clear liquid to 100ml, filter, sub-package, and sterilize to prepare a compound sulfamethoxine injection.

Embodiment 2

[0043] A preparation method of compound sulfamethoxine injection, comprising the steps of:

[0044] (1). Weigh 60ml of propylene glycol and heat to 90°C; (2). Add 3g of TMP, 9g of sulfamethoxine, and 7g of deoxyoxytetracycline, stir and dissolve to form solution A; (3). Add 2ml of water for injection Add 0.2g of diabolite powder, stir and dissolve to form solution B; (4). Pour solution B into solution A, then heat to dissolve until clear to form a clear liquid; (5). Adjust with HCL or ethanolamine The pH of the clarified liquid is 7.0, then add water for injection to make the clarified liquid to 100ml, filter, sub-package, and sterilize to make a compound sulfamethoxine injection.

Embodiment 3

[0046] A preparation method of compound sulfamethoxine injection, comprising the steps of:

[0047] (1). Weigh 80ml of glycerol and heat to 70°C; (2). Add 1g of TMP, 11g of sulfamethoxine, 3g of deoxyoxytetracycline, stir and dissolve to form solution A; (3). Add 0.1 g of sodium sulfite to water for injection, stir to dissolve to form solution B; (4). Pour solution B into solution A, then heat to dissolve until clear to form a clear solution; (5). Use HCL or ethanolamine Adjust the pH of the clear liquid to be 6.5, then add water for injection to make the clear liquid to 100ml, filter, sub-package, and sterilize to make a compound sulfamethoxine injection.

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PUM

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Abstract

The invention relates to compound sulfamonomethoxine injection and a preparation method of the compound sulfamonomethoxine injection. The injection comprises main drug, antioxidant, solvent for injection and water for injection. The preparation method is that the sulfamonomethoxine and trimethoprim (TMP) are used together, which can doubly block folate metabolism of bacteria; under the bidirectional cooperative effect between cyclooxygenase and ethyl inhibitor, the sulfamonomethoxine and doxycycline cooperate, so the drug absorption is fast and the toxicity is reduced with better efficacy and more safety. With scientific compatibility, lower cost and simple and easy preparation method, the invention is suitable for industrialized mass production.

Description

technical field [0001] The invention belongs to the field of chemical preparations, in particular to a compound sulfamethoxine injection and a preparation method thereof. Background technique [0002] There are many kinds of animal diseases in my country, among which bacterial diseases account for more than 60%, followed by viral infections and parasitic infections, such as streptococcus, Eperythrozoon, Toxoplasma gondii, etc., which have caused huge economic losses to farmers and severely restricted With the development of animal husbandry. [0003] Sulfamethoxine is the most effective of the sulfonamides. It has a strong inhibitory effect on most Gram-positive and Gram-negative bacteria. Bacteria develop resistance to this drug slowly. Sulfamethoxine is mainly used for various diseases caused by sensitive bacteria, and it also has a good curative effect on toxoplasmosis, edema, and coccidiosis; it is characterized by good oral absorption, high blood concentration, and low ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61K47/02A61K47/10A61K47/22A61P31/04A61K31/635A61K31/505
Inventor 张兴龙华云芳许新增
Owner 浙江道格凯特实业有限公司
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