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Method for producing chitosan oligosaccharide with self-warming up oxidative degradation

A technology of chitosan oligosaccharide and chitosan, which is applied in the direction of oligosaccharides, etc., can solve the problems of poor physiological activity, low average molecular weight, and difficult separation, and achieve the effect of preventing dark color, good sensory, and uniform reaction speed

Inactive Publication Date: 2008-07-16
杨志强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method requires external heating to maintain the temperature of the reaction system at 60-80°C; Na ions are introduced in the reaction, which makes separation difficult; the hydrogen peroxide added in the reaction is added at one time, and the amount added is relatively large. The weight ratio of hydrogen peroxide is 1:2~4, so that the average molecular weight of the reaction product is too low, which is 609 Daltons, resulting in poor physiological activity of the product for medicinal purposes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1. Add 7kg of water into the reaction container, heat the water to 30°C; then add 2Kg of chitosan with a molecular weight of 450,000 Daltons into the container, stir evenly to infiltrate the raw material evenly.

[0019] 2. Add 1.5Kg of hydrogen peroxide (mass concentration is 35%) aqueous solution into the chitosan soaking solution, and mix well. At this time, the mass concentration of chitosan in the mixed material was 19%, and the mass concentration of hydrogen peroxide was 5%.

[0020] 3. Immediately add 100ml of glacial acetic acid to the above mixed solution, and stir well. At this time, the pH value of the mixed material is between 6 and 7.

[0021] 4. After the above materials are added, the degradation reaction starts, and the temperature of the materials also rises slowly. After the reaction was carried out for 50 minutes, 0.5 Kg of hydrogen peroxide (mass concentration: 35%) aqueous solution was added to the material and mixed evenly.

[0022] 5. After the ...

Embodiment 2

[0030] 1. Add 7kg of water into the reaction container, heat the water to 60°C; then add 2Kg of chitosan with a molecular weight of 450,000 Daltons into the container, stir evenly to infiltrate the raw material evenly.

[0031] 2. Add 1.0Kg of hydrogen peroxide (mass concentration is 35%) aqueous solution into the chitosan soaking solution, and mix well. At this time, the mass concentration of chitosan in the mixed material was 20%, and the mass concentration of hydrogen peroxide was 3.5%.

[0032] 3. Immediately add 100ml of glacial acetic acid to the above mixed solution, and stir well. At this time, the pH value of the mixed material is between 6 and 7.

[0033] 4. After the above materials are added, the degradation reaction starts, and the temperature of the materials also rises slowly. After the reaction was carried out for 30 minutes, 1 Kg of hydrogen peroxide (mass concentration: 35%) aqueous solution was added to the material and mixed evenly.

[0034] 5. After the ...

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Abstract

The invention relates to a preparation method of a chito-oligosaccharide, which is precisely a chito-oligosaccharide preparation method by means of self reaction heating and oxidation degradation. The invention firstly heats the water to a temperature of 25 to 60 DEG C, then puts high molecular weight chito-oligosaccharide raw material into the water and mixes well, whereafter adds hydrogen peroxide aqueous and acid and mixes well, and then the degradation reaction begins. The oxidation degradation reaction is exothermic, which needs no extra energy supply for the reaction system after the reaction begins. As the reaction carries on, the material gradually heats while the reaction speed gradually quickens. The even chito-oligosaccharide solution is gained after about two hours when the reaction completes, from which the chito-oligosaccharide powder with less than 2000 Dalton average molecular weight, narrow molecular weight distribution and high physiological activity effective polysaccharide with high content can be gained through direct spray drying, vacuum drying or lyophilization or drying after condensation. The preparation method of the invention can maintain the reaction system in higher temperature without heating for a long period, which needs very few production equipment investment and is characterized by simplicity, convenience, safety, economy, utility, high efficiency, low production cost and having no influence on the environment , etc.

Description

technical field [0001] The invention relates to a method for preparing chitosan oligosaccharides through oxidative degradation by utilizing reaction self-heating to maintain a reaction system at a lower suitable temperature. Background technique [0002] Chitosan is a glucosamine polysaccharide with a degree of deacetylation of more than 70% obtained by deacetylation of chitin. It contains free amino groups in its molecule and is the only alkaline polysaccharide among natural polysaccharides. The molecular weight of chitosan is usually about hundreds of thousands. Because of the hydrogen bond in the molecule, it can only be dissolved in a few dilute acid solutions, but not directly in water, so its application range is greatly limited. Oligochitosan refers to chitosan with an average molecular weight lower than 2000 Daltons. Chitosan with different molecular weights has different effects. The physiological activity of chitosan oligosaccharides is closely related to their mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H3/06
Inventor 杨志强
Owner 杨志强
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