Medicine compounds for treating pharyngitis sicca

A composition and drying technology, applied in the field of medicine, can solve problems such as inconvenience for patients to take medication, and achieve the effects of convenient administration, reduced adverse reactions, and high local concentration

Inactive Publication Date: 2008-07-30
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the way of administration is pharyngeal injection, which is not convenient for patients to take medication
[0006] So far, there is no very ideal drug for the treatment of pharyngitis sicca clinically.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 Hanhua Tablet Prescription and Preparation Technology

[0019] Pilocarpine 1.9g

[0020] Tetracaine 0.05g

[0021] Starch 120g

[0022] Dextrin 75g

[0023] Sodium saccharin 2g

[0024] Magnesium stearate 3g

[0025] 95% ethanol solution appropriate amount

[0026] Preparation Process:

[0027] Mix the prescribed amount of pilocarpine, tetracaine, starch, dextrin, and sodium saccharin evenly, crush through a 100-mesh sieve, add an appropriate amount of 95% ethanol solution as a wetting agent, stir for 8 minutes, pass through a 40-mesh sieve, and then granulate , dried at 40°C, granulated, added with magnesium stearate, mixed evenly, pressed into 1000 tablets, and obtained.

Embodiment 2

[0028] Embodiment 2 Hanhua Tablet Prescription and Preparation Technology

[0029] Pilocarpine 1.2g

[0030] Lidocaine 0.6g

[0031] Mannitol 135g

[0032] Dextrin 20g

[0033] Aspartame 1.5g

[0034] Magnesium stearate 2g

[0035] 95% ethanol solution appropriate amount

[0036] Preparation Process:

[0037] Mix the prescribed amount of pilocarpine, lidocaine, mannitol, dextrin, and aspartame evenly, then pulverize and pass through a 100-mesh sieve, add an appropriate amount of 95% ethanol solution as a wetting agent, stir for 8 minutes, and pass through a 40-mesh sieve Then granulate, dry at 40°C, granulate, add magnesium stearate, mix evenly, and press 1000 tablets to obtain.

Embodiment 3

[0038] Embodiment 3 Han Hua tablet prescription and preparation technology

[0039] Pilocarpine 2g

[0040] Lidocaine 0.5g

[0041] Lactose 100g

[0042] Dextrin 50g

[0043] Sucralose 3g

[0044] Magnesium stearate 2.5g

[0045] 95% ethanol solution appropriate amount

[0046] Preparation Process:

[0047] Mix the prescribed amount of pilocarpine, lidocaine, lactose, dextrin, and sucralose evenly, crush them through a 100-mesh sieve, add an appropriate amount of 95% ethanol solution as a wetting agent, stir for 8 minutes, pass through a 40-mesh sieve, and then granulate , dried at 40°C, granulated, added with magnesium stearate, mixed evenly, pressed into 1000 tablets, and obtained.

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PUM

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Abstract

The invention provides a drug composition curing pharyngitis sicca and comprises pilocarpine and lidocaine or tetracaine with a good synergistic effect in improving pharyngitis sicca symptoms of patients. The invention which is significant in efficacy and good in treatment effect also provides a preparation method and process for dissolving tablets in mouth of the drug composition which preferably chooses the dissolving tablets in mouth which are convenient for patients to take.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for treating pharyngitis sicca and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Chronic pharyngitis is a chronic inflammation of the pharyngeal mucosa, often a part of chronic inflammation of the respiratory tract. It is mostly caused by repeated episodes of acute pharyngitis or delayed treatment and becoming chronic or various nasal diseases caused by long-term mouth breathing and nasal secretions flowing down due to nasal obstruction, resulting in long-term stimulation of the pharynx, or chronic tonsillitis, dental caries and other effects. It can be stimulated by various physical and chemical factors: such as dust, neck radiotherapy, long-term exposure to chemical gases, excessive smoking and alcohol, etc. In addition, systemic factors such as various chronic diseases can secondary to this disease. Mainly divided into chronic simple pharyngitis,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4178A61K31/167A61K31/245A61K9/20A61P11/04
Inventor 孙勇徐丽洒徐平沈若武刘占涛
Owner QINGDAO UNIV
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