New purpose of aminoperhydro-quinazoline compounds for eliminating clenbnterol in organisms

A hydrogenated quinazoline and compound technology, which is applied in the new application field of aminoperhydroquinazoline compounds to remove clenbuterol from living organisms, and can solve the problems of long metabolic half-life, small tolerance, slow metabolism and the like

Active Publication Date: 2008-08-13
江苏宏锦天药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clenbuterol hydrochloride has a long metabolic half-life, slow metabolism in the human body, and is easy to accumulate in t...

Method used

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  • New purpose of aminoperhydro-quinazoline compounds for eliminating clenbnterol in organisms
  • New purpose of aminoperhydro-quinazoline compounds for eliminating clenbnterol in organisms
  • New purpose of aminoperhydro-quinazoline compounds for eliminating clenbnterol in organisms

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0223] Example 1, get tetrodotoxin (TTX), content (95-99%) 10mg, use 150 μ g of citric acid, be mixed with the solution of PH=5.0-7.0, calculate by every 2ml containing 10ug, make 1000 injections, use HPLC After the test, the content is qualified, filled and sterilized, and it meets the medical hygiene standard or veterinary standard, and then it can be used, referred to as: Tetrodotoxin Salt A.

example 2

[0224] Example 2, get deoxytetrodotoxin, content (85-98%) 1mg, use oxalic acid 150 μ g, g is formulated into the solution of PH=5.0-7.0, calculate by every 2ml containing 10ug, make 1000 injections, detect with PLC, After the content is qualified, it can be filled and sterilized, and it can be used after meeting the medical hygiene standards or veterinary standards. It is referred to as Tetrodotoxin B.

example 3

[0225] Example 3, get tetrodotoxin acid, content (85-95%) 1mg, use 150 μ g of malic acid, be mixed with the solution of PH=5.0-7.0, calculate by containing 10ug per 2ml, make 1000 injections, detect with PLC, After the content is qualified, it can be filled and sterilized, and it can be used after meeting the medical hygiene standards or veterinary standards. It is referred to as Tetrodotoxin C.

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PUM

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Abstract

The invention relates to a compound of the amino perhydrogenated quinazoline (tetraodontoxin) class, the ramification of the compound, and the medical salt class of the compound, in particular to a new usage of the compound in clearing the medicine of the clenbuterol hydrochloride (clenbuterol in brief) class which remains in the bodies of the raised animals or aquatic organism. The clenbuterol is illegally added to promote the growth of the animals and aquatic organism in the present aquatic organism breeding and poultry raising. If the animals or aquatic organism with clenbuterol are eaten by people, human bodies will be endangered. The invention is characterized in that the chemical ingredients and medical salt of the amino perhydrogenated quinazoline class are adopted so as to make a medicine or animal medicine to be used by the raised animals or aquatic organism, so that the chemical ingredients of the clenbuterol remaining in the bodies of the raised animals or aquatic organism can be discharged outside and the compound of the amino perhydrogenated quinazoline does not remain in the bodies of the raised animals or aquatic organism.

Description

technical field [0001] The invention relates to a new application of amino perhydroquinazoline compounds and medicinal salts or esters of their derivatives in the preparation and removal of clenbuterol hydrochloride (clenbuterol) drug residues in farmed animals and aquatic organisms. Background technique [0002] Amino perhydroquinazoline compounds and their derivatives are represented by tetrodotoxin, a class of clathrate orthoester alkaloid small molecule chemical components extracted from natural aquatic organisms or biological fermentation or artificially synthesized. [0003] Tetrodotoxin (TTX) compounds were first isolated from puffer fish (Fugu vermicularis), T.Goto et al., Tetrahedron, 21, 2059 (1965), E.F.Murtha., Expte, Therap.122, 246 (1958 ) published in the literature. Tetrodotoxin has been found to contain tetrodotoxin in nearly a hundred species of puffer fish such as Tetrodontidae, Triodntiadae, Molidae, and Triodntiade, and gobies have also been reported in...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61P43/00C07D491/22
Inventor 邱芳龙姚土生陈一平
Owner 江苏宏锦天药业有限公司
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