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Method for improving vitamin C Yinqiao tablet stability

A technology of stability and Yinqiao, which is applied in the field of improving the stability of vitamin C Yinqiao tablets, can solve problems such as failure to achieve ideal results, achieve the effects of improving content stability, reducing production costs, and improving product quality

Active Publication Date: 2011-07-20
GUANGXI YINGKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it has been reported that the coating auxiliary materials used include hydroxypropyl methylcellulose, ethyl cellulose, acrylic resin, etc., but most of them still fail to achieve the desired effect.

Method used

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  • Method for improving vitamin C Yinqiao tablet stability
  • Method for improving vitamin C Yinqiao tablet stability
  • Method for improving vitamin C Yinqiao tablet stability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Example 1: Preparation of Vitamin C Yinqiao Tablets

[0008] The formula of Vitamin C Yinqiao Tablets:

[0009] Honeysuckle 1800g Forsythia 1800g Nepeta 720g

[0010] 900g light tempeh, 20g light bamboo leaves, 1080g burdock

[0011] Reed root 1080g Bellflower 1080g Licorice 900g

[0012] Chlorpheniramine Maleate 10.5g Acetaminophen 1050g Vitamin C 495g

[0013] Peppermint oil 10.8ml

[0014] Excipients: Gelatin, Ethanol, Starch, Talc, Magnesium Stearate

[0015] Preparation process steps:

[0016] (1) Extract volatile oils from honeysuckle, forsythia, and nepeta respectively, and combine the volatile oils for later use.

[0017] (2) After extracting the volatile oil, decoct the dregs of the medicine with the bamboo leaves, tempeh, reed root, bellflower, and licorice twice for 2 hours each time, filter, and combine the filtrate for later use.

[0018] (3) Burdock fruit is extracted twice with 60% ethanol under reflux, each time for 4 hours, filter, combine the fi...

Embodiment 2

[0022] Example 2: Preparation of Vitamin C Yinqiao Tablets

[0023] The formula and preparation method are the same as in Example 1. The difference from Example 1 is that the gelatin slurry whose weight is 15% of the vitamin C raw material powder is sprayed, and stirred until the vitamin C is moistened while adding, and the hot air is turned on until it is dry. After drying, the coarse powder is finely ground and sieved with a 30 mesh sieve , the fine particles continue to be coated, so repeated 4 layers, to obtain vitamin C particles. Then place the vitamin C microparticles in a multi-directional motion mixer and mix for 18 minutes, take them out, measure the content, and set aside.

Embodiment 3

[0024] Embodiment 3: Stability test is carried out to the vitamin C Yinqiao tablet produced by the method of embodiment 1

[0025] The situation and results of the stability test are as follows:

[0026] Prepared 6 batches of products by the preparation technology of embodiment 1, batch number is: 060111, 060114, 060116, 040203, 040204, 040205, every 30 are encapsulated in 35ml oral solid medicinal high-density polyethylene bottle, and a carton (i.e. (Packaging conditions for marketing), placed for 12 months at a temperature of 25°C±2°C and a relative humidity of 60±10%, sampling once every 3 months, respectively at 0 month, 3 months, 6 months, At 9 months and 12 months, testing will be carried out according to the key inspection items of stability. After 12 months, samples were taken for testing at 18 and 24 months respectively.

[0027] 1. Testing basis: National Drug Standard WS3-B-4000-98-2003.

[0028] 2. Test items: traits, identification, inspection, content determin...

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Abstract

The invention relates to a method for improving the stability of the vitamin C Yinqiao tablet. The invention is characterized in that the coated vitamin C adopts the preparing method that: vitamin C material powder is put into a sugar coating pot, 15 to 25 percent of gelatin size is sprayed into the pot, simultaneously the powder is stirred, hot air is opened until the powder is dried, the coarsepowder is sieved and filtered through a 30-mesh sieve, the fine grain is coated right along, the operation is repeated for 4 to 6 layers, and then the vitamin C fine particle is achieved; then the vitamin C fine particle is mixed for 12 to 18 minutes on a multi-direction movement mixer, then is taken out, and the content is measured for standby application. After the vitamin C fine particle is prepared through the technology of the invention, the further pelletization method is adopted for pelletization and the compressing dry granulation technology is adopted to prepare the vitamin C Yinqiaotablet, the content stability of the vitamin C Yinqiao tablet is greatly improved, the effective period of the product is more than 2 years, and the cost of the product is reduced.

Description

technical field [0001] The invention relates to a method for improving the stability of vitamin C Yinqiao tablet. Background technique [0002] Vitamin C Yinqiao Tablets is a widely used combination of traditional Chinese and Western medicine to treat colds. Because the vitamin C in the formula is easily oxidized, the content during the shelf life cannot meet the requirements and the quality is unstable; the new drug quality standards in 2002 stipulated that vitamin C needs Vitamin C particles are made into vitamin C particles after coating with auxiliary materials to increase the stability of vitamin C tablets; therefore, it is very critical to choose suitable coating auxiliary materials. At present, it has been reported that the coating auxiliary materials used include hydroxypropyl methylcellulose, ethyl cellulose, acrylic resin, etc., but most of them still fail to achieve the desired effect. Contents of the invention [0003] The technical problem to be solved by the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/375A61K31/4402A61K47/42
Inventor 梁峰宾祖焕黄若干张伟黄平权杨志坚
Owner GUANGXI YINGKANG PHARMA
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