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Use of garlic oil in preparing medicine against acute alcoholic fatty liver

A technology of alcoholic fatty liver and garlic oil, applied in the field of garlic oil, can solve the problem that there is no anti-acute alcoholic fatty liver effect and the like

Active Publication Date: 2011-08-03
山东淄博新达制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many reports at home and abroad that garlic has the functions of anti-cancer, lowering blood pressure, lowering blood fat, preventing atherosclerosis, and regulating immunity.
At present, there is no report on the anti-acute alcoholic fatty liver effect

Method used

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  • Use of garlic oil in preparing medicine against acute alcoholic fatty liver
  • Use of garlic oil in preparing medicine against acute alcoholic fatty liver
  • Use of garlic oil in preparing medicine against acute alcoholic fatty liver

Examples

Experimental program
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Effect test

Embodiment Construction

[0008] In order to better understand the essence of the present invention, the effect of garlic oil in anti-acute alcoholic fatty liver is illustrated by the experimental results of garlic oil against acute alcoholic fatty liver in mice:

[0009] 1. Materials and methods

[0010] 1.1 Materials:

[0011] Garlic oil was provided by Xuchang Yuanhua Biotechnology Co., Ltd.; SPF grade healthy male Kunming mice, weighing 18-22g, were provided by the Experimental Animal Center of Shandong University; the triglyceride (TG) kit was provided by Zhongsheng Beikong Biotechnology Co., Ltd. Products; automatic biochemical analyzer (BTS370, Spain); ultraviolet / visible spectrophotometer (Shimadzu, Japan).

[0012] 1.2 Method:

[0013] Seventy-five male healthy Kunming mice were randomly divided into five groups, namely control group, ethanol model group, low-, medium-, and high-dose garlic oil groups, with 15 mice in each group. The doses of garlic oil low, medium and high dose groups were...

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Abstract

The invention discloses the new use of garlic oil, namely the application of the garlic oil in preparing the medicaments used for resist acute alcoholic fatty liver. 50 to 200 mg of garlic oil is contained in the medicaments resisting acute alcoholic fatty liver caused by alcohol of 4.8g / kg.bw per kilogram of body. The garlic oil is taken orally, and is taken two hours prior to drinking. Before the garlic oil is taken, the garlic oil can be diluted with corn oil. Proven through experiments on mice, the garlic oil can significantly reduce the liver index, sera TG, liver TG, and inhibit liver MDA l from rising caused by ethano, and can increase the content of GSH in the liver, which has the function of resisting acute alcoholic fatty liver. The garlic oil can be used for preparing medicaments for resisting acute alcoholic fatty liver, and establishes a new application way for preventing alcoholic hepatopathy.

Description

technical field [0001] The invention relates to a new application of garlic oil, in particular to the application of garlic oil in the preparation of anti-acute alcoholic fatty liver medicine. Background technique [0002] Garlic (allium sativum L.) is the bulb of garlic, a plant of the genus Allium in the Liliaceae family. Traditional Chinese medicine believes that garlic has the effects of stagnant qi, warming the spleen and stomach, eliminating blood stasis, detoxifying and killing insects. Sores, snake bites. Garlic oil is an oily substance extracted from garlic, which contains various sulfur-containing functional components such as allicin, ajoene and allitridin. Garlic's antibacterial and anti-inflammatory, insecticidal, anti-cancer, lowering blood pressure, lowering blood fat, preventing atherosclerosis, and regulating immune function are all related to garlic oil. There are many reports at home and abroad that garlic has the functions of anti-cancer, lowering bloo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8962A61P1/16A61K125/00
Inventor 谢克勤曾涛张翠丽赵秀兰于丽华宋富永
Owner 山东淄博新达制药有限公司
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