Antibiotic//TCP composite nano-material and preparation method thereof

Abstract

The invention pertains to the technical field of a new material of medicines, relating to antibiotic / TCP nanocomposite and a method thereof. The antibiotic / TCP nanocomposite provided by the invention is a ball-type porous material which consists of antibiotic and TCP and the matter motes with nanometer size are absorbed on the supporting framework of organic matter. The adjustable range of the ball-type size is from a plurality of hundred nanometers to dozens of microns. The surface of the ball is provided with a portiforium structure. The antibiotic / TCP nanocomposite is a new-type anti-infective bone implanting material which has high drug loading and good re-absorption rate and can control slow releasing rate of drugs.

Description

technical field [0001] The invention belongs to the technical field of new medical materials, and relates to an antibiotic / TCP composite nano material and a preparation method thereof. Background technique [0002] In recent years, my country's industrial level and expressways have developed rapidly, and the safety assurance level of dangerous industries such as mining and construction is still very low. On average, more than 700,000 accidents of various types occur every year, and more than 700,000 people are disabled. Among them, open fractures are seriously polluted and easily lead to bone infection and osteomyelitis. Treatment is difficult and expensive. The pathogenic bacteria are stubborn, and it is extremely difficult to completely remove them through surgery. In addition, the infected bone and surrounding tissues are secondary to chronic ischemia. It is difficult to obtain an ideal antibacterial concentration in the local area with antibiotics used throughout the bod...

AI Technical Summary

Problems solved by technology

On average, more than 700,000 accidents of various types occur every year, and more than 700,000 people are disabled. Among them, open fractures are seriously polluted, which can easily lead to bone infection and osteomyelitis. Treatment is difficult and expensive.

The pathogenic bacteria are stubborn, and it is extremely difficult to completely remove them through surgery. In addition, the infected bone and surrounding tissues are secondary to chronic ischemia. It is difficult to obtain an ideal antibacterial concentration in the local area with antibiotics used throughout the body. Local implantation of antibiotic bone cement can improve local The drug concentration can exert effective antibacterial activity, but the antibiotic elution rate of the bone cement is only 5%, and the bone cement cannot be reabsorbed, so a second operation is required to remove it

Although there are some products on the market, either they are not sensitive to the antibacterial spectrum of antibiotics, or their materials are difficult to absorb after being implanted into the human body, so far there is no ideal product

[0003] At present, the clinical bacterial spectrum has changed significantly compared with the past. Most of them are methicillin-resistant Staphylococcus aureus (MRSA), which is resistant to all penicillins and cephalosporins. Osteomyelitis is the most difficult to treat

Vancomycin has extremely high in vitro antibacterial activity against MRSA, and is an effective drug for treating severe MRSA infections. It also has extremely high antibacterial activity against Clostridium, which are the most common in refractory osteomyelitis bacteria, but systemic use often has serious side effects of nephrotoxicity and ototoxicity reported, so local vancomycin drug sustained release system is the most ideal method for the treatment of MRSA bone infection

[0004] Foreign countries have begun to carry vancomycin artificial bone research, but the literature reports that the drug loading is unstable, unable to control the release, and it is difficult to maintain the antibacterial effect