Antibiotic//TCP composite nano-material and preparation method thereof

A technology of composite nanomaterials and antibiotics, applied in medical science, prosthesis, etc., can solve the problems of insensitive antibiotic spectrum, infectious osteomyelitis, difficult treatment, etc., and achieve the effect of wide clinical application.

Inactive Publication Date: 2008-12-10
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On average, more than 700,000 accidents of various types occur every year, and more than 700,000 people are disabled. Among them, open fractures are seriously polluted, which can easily lead to bone infection and osteomyelitis. Treatment is difficult and expensive.
The pathogenic bacteria are stubborn, and it is extremely difficult to completely remove them through surgery. In addition, the infected bone and surrounding tissues are secondary to chronic ischemia. It is difficult to obtain an ideal antibacterial concentration in the local area with antibiotics used throughout the body. Local implantation of antibiotic bone cement can improve local The drug concentration can exert effective antibacterial activity, but the antibiotic elution rate of the bone cement is only 5%, and the bone cement cannot be reabsorbed, so a second operation is required to remove it
Although there are some products on the market, either they are not sensitive to the antibacterial spectrum of antibiotics, or their materials are difficult to absorb after bein

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1) Preparation of antibiotic / TCP sol:

[0040] With Ca(NO 3 ) 2 content above 95%, H 3 PO 4 content of more than 65%, the antibiotics are vancomycin and tobramycin, as the main raw materials for the preparation of antibiotic / TCP sol,

[0041] Ca(NO 3 ) 2 、H 3 PO 4 1. Antibiotics and water are prepared in a closed container according to the required ratio, and the pH value is adjusted to 5.5-10.5 under the stirring of an electric mixer, and the antibiotic / TCP sol is obtained after stirring at 30°C-60°C for half an hour;

[0042] 2) Prepare polycaprolactone (PCL) of desired molecular weight:

[0043]With caprolactone (CL) as a monomer, lanthanide metal compounds such as copper acetylacetonate, etc., or organometallic compounds such as butyl titanate, etc., as catalysts, hydrocarbons as solvents, under the protection of nitrogen atmosphere, more than Under the temperature condition of 80° C., and reacted for 2 hours under stirring conditions, a polycaprolactone so...

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PUM

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Abstract

The invention pertains to the technical field of a new material of medicines, relating to antibiotic /TCP nanocomposite and a method thereof. The antibiotic /TCP nanocomposite provided by the invention is a ball-type porous material which consists of antibiotic and TCP and the matter motes with nanometer size are absorbed on the supporting framework of organic matter. The adjustable range of the ball-type size is from a plurality of hundred nanometers to dozens of microns. The surface of the ball is provided with a portiforium structure. The antibiotic /TCP nanocomposite is a new-type anti-infective bone implanting material which has high drug loading and good re-absorption rate and can control slow releasing rate of drugs.

Description

technical field [0001] The invention belongs to the technical field of new medical materials, and relates to an antibiotic / TCP composite nano material and a preparation method thereof. Background technique [0002] In recent years, my country's industrial level and expressways have developed rapidly, and the safety assurance level of dangerous industries such as mining and construction is still very low. On average, more than 700,000 accidents of various types occur every year, and more than 700,000 people are disabled. Among them, open fractures are seriously polluted and easily lead to bone infection and osteomyelitis. Treatment is difficult and expensive. The pathogenic bacteria are stubborn, and it is extremely difficult to completely remove them through surgery. In addition, the infected bone and surrounding tissues are secondary to chronic ischemia. It is difficult to obtain an ideal antibacterial concentration in the local area with antibiotics used throughout the bod...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/54A61L27/56
Inventor 董健徐子颉罗楹方涛林吴俊罗苹戴文达卢懿李云飞
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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