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Compounds for the treatment of auricular fibrillation

一种心房颤动、化合物的技术，应用在治疗心血管疾病的化合物,治疗心房颤动的化合物领域，能够解决心房颤动没有得到满意的解决等问题

Inactive Publication Date: 2008-12-17
PROYECTO DE BIOMEDICINA CIMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the problem of treating atrial fibrillation is far from being satisfactorily resolved

Method used

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  • Compounds for the treatment of auricular fibrillation
  • Compounds for the treatment of auricular fibrillation
  • Compounds for the treatment of auricular fibrillation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0046] Detailed description of the drawings

[0047] Figure 1A Indicates the newly isolated human right atrial myocytes, which use anti-A 2A Receptors (frames 1, 4, 7, and 10) and anti-myosin (frame 2), anti-α-actinin (frame 5), anti-connexin-43 (frame 8), or anti-RyR (Panel 11) Double dyeing. The superimposition of the double immunofluorescence images (3, 6, 9 and 12) revealed that the A 2A Co-localization of receptor and α-actinin and A 2A The overlapping distribution of the receptor and the ryanodine receptor RyR. Figure 1B Showing human A from transient transfection 2A The cell membrane of the recipient's HEK cell (positive control, C+) and the human atrial heart membrane obtained from individuals with sinus rhythm (SINUS) or atrial fibrillation (AF), which were analyzed by SDS-PAGE and used rabbit anti-A 2A Immunoblotting was performed with receptor antibodies. "Di" means dimer and "mono" means monomer. Figure 1C display Figure 1B Relative Densitometer Scan (RDS) of th...

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Abstract

The invention relates to antagonists of the adenosine A2A receptor, which can be used for the preparation of medicaments for auricular fibrillation in mammals, including humans. It has been found that the A2A adenosine receptor is present in human auricular cardiomyocytes and involved in the basic pathological mechanisms of auricular fibrillation. The use of A2A antagonists is advantageous over other known agents in that A2A antagonists are directed specifically to patients with auricular fibrillation.

Description

Technical field [0001] The present invention relates to the fields of human medicine and veterinary medicine, and specifically relates to compounds for the treatment of cardiovascular diseases, in particular, compounds for the treatment of atrial fibrillation. Background technique [0002] Atrial fibrillation is the most common arrhythmia and is associated with substantial morbidity and mortality. Its morbidity and prevalence are increasing and mean an increasing clinical burden and economic burden (the current prevalence is 2% of the total population). In addition to severe clinical symptoms such as palpitations, dizziness, dyspnea, and other serious clinical symptoms, atrial fibrillation is the single most important factor of ischemic stroke in people over 75 years of age. In general, atrial fibrillation accounts for more than 5% of cardiovascular diseases accepted in hospitals. In about 90% of cases, atrial fibrillation occurs in the presence of other heart diseases such as hy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K31/42A61K31/498A61K31/519A61K31/53A61K31/4709
CPCA61K31/42A61K31/4709A61K31/498A61K31/519A61K31/522A61K31/53A61P9/00A61P9/06
Inventor 拉斐尔·弗朗克费尔南德兹弗朗西斯科·斯如拉阿尔费瑞兹卡门·路易斯比萨特克里斯塔·穆勒让·辛卡库斯库洛拉雷夫·浩乌-马德森
Owner PROYECTO DE BIOMEDICINA CIMA
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