Application of Forsythoside A in preparing antineoplastic chemotherapy sensitivity-enhancing toxicity-reducing medicament or anti-AIDS sensitivity-enhancing toxicity-reducing medicament

An anti-AIDS and forsythiaside technology, applied in the field of pharmaceuticals, can solve the problems of no forsythiaside anti-AIDS virus research, no reported side effects of forsythiaside, increase the efficacy of chemotherapy drugs, etc.

Inactive Publication Date: 2009-01-14
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, researchers have prepared forsythiaside into freeze-dried powder for anti-influenza virus, syncytial virus, adenovirus, Coxsackie virus, etc., but there is no research on forsythiaside for anti-HIV However, there is no report that forsythiaside can improve the side effects caused by anti-AIDS drugs
In addition, there are no relevant reports on the combination of forsythiaside and chemotherapy drugs to increase the efficacy of chemotherapy drugs and reduce the toxicity of chemotherapy drugs

Method used

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  • Application of Forsythoside A in preparing antineoplastic chemotherapy sensitivity-enhancing toxicity-reducing medicament or anti-AIDS sensitivity-enhancing toxicity-reducing medicament
  • Application of Forsythoside A in preparing antineoplastic chemotherapy sensitivity-enhancing toxicity-reducing medicament or anti-AIDS sensitivity-enhancing toxicity-reducing medicament
  • Application of Forsythoside A in preparing antineoplastic chemotherapy sensitivity-enhancing toxicity-reducing medicament or anti-AIDS sensitivity-enhancing toxicity-reducing medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: The composition consists of 1000 capsules of forsythiaside (purchased from Shanghai Pharmaceutical Industry Research Institute, the same below) and 400-499 grams of cellulose. The preparation method is as follows: granulating forsythiaside and cellulose, and then compressing into tablets or filling capsules, and each capsule (tablet) contains 1-100 mg of forsythiaside.

Embodiment 2

[0017] Example 2: Add 1-100 grams of forsythiaside to 1 liter of water for injection, and pack it into 1000 sticks. The preparation method is as follows: dissolve forsythiaside in water for injection, add to 1 liter, sterilize, and pack separately. Each tube contains 1-100mg forsythiaside.

[0018] Study on Anti-tumor Synergistic and Toxic Attenuation of Forsythiaside

[0019] 1. Study on synergistic antitumor effect of forsythiaside and chemotherapeutic drugs

[0020] (1) Experimental method

[0021] Divide the experimental group into two groups:

[0022] Chemotherapy drug cisplatin treatment group: (1) normal control group; (2) cisplatin model group (10 μg / ml); (3) cisplatin + forsythiaside 1 group (cisplatin 10 μg / ml + forsythiaside 10 μg / ml); (4) cisplatin + forsythiaside 2 groups (cisplatin 10 μg / ml + forsythiaside 2 μg / ml); (5) cisplatin + forsythiaside 3 groups (cisplatin 10 μg / ml + forsythiaside 2 (6) cisplatin + forsythiaside 4 groups (cisplatin 10 μg / ml + forsy...

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Abstract

The present invention relates to the applications of forsythia ester glycoside in preparing a sensitivity-enhancing and toxicity-reducing medicine in resisting tumor chemotherapy or AIDS. The present invention is a medicinal compound prepared by forsythia ester glycoside and pharmaceutical carrier and / or excipient. The prepared medicinal compound is used for enhancing sensitivity and reducing toxicity in resisting tumor chemotherapy or AIDS, which has the advantages of good curing effect, less side effects and increasing the living quality of patients.

Description

technical field [0001] The present invention relates to the use of forsythiaside, in particular to the use in the field of pharmacy. Background technique [0002] Chemotherapy is an important means of treating cancer at present. While chemotherapy drugs kill cancer cells, they are also toxic to normal cells in the body. In recent years, with the continuous emergence of new anti-cancer drugs and the rational application of combined chemotherapy regimens, the curative effect of chemotherapy has been greatly improved, but these drugs also have damage or toxicity to normal tissues and organs, thereby reducing the immune function of the body, and the occurrence of A series of toxic and side effects such as bone marrow suppression affect the efficacy of chemotherapy and even force the termination of chemotherapy. Clinical studies have shown that during chemotherapy, according to the patient's constitution, cancer stage, and symptoms of toxic and side effects, supplemented with tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7028A61P35/00A61P31/18
Inventor 丁虹陆伟根谢燕莺
Owner WUHAN UNIV
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