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New use of thymosin alpha1

A technology of thymosin and diabetes drugs, applied in new application fields, can solve problems such as kidney enlargement, decreased serum antioxidant capacity, and thymus atrophy, so as to enhance glucose tolerance, protect the structure and function of pancreatic islet cells, and slow down weight gain Effect

Inactive Publication Date: 2009-02-11
XIAMEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Induced mouse thymus atrophy, kidney enlargement, and serum antioxidant capacity decreased significantly

Method used

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  • New use of thymosin alpha1
  • New use of thymosin alpha1
  • New use of thymosin alpha1

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0032] The following embodiments will further illustrate the present invention in conjunction with the accompanying drawings.

[0033] The materials and methods used in the examples are described below.

[0034] 1. Experimental materials and main biological reagents

[0035] The experimental animals were C57BL / 6 mice, (20 ± 2) g, 6-7 weeks old, male, SPF grade, 60 mice, provided by Shanghai Slack Experimental Animal Co., Ltd., certificate number: SCXK (Shanghai )200320003. Single-cage feeding, room temperature 18-25°C, relative temperature 50%-80%, daily light for 12h, free access to food and water.

[0036] Streptozotocin (streptozotocin STZ, SIGMA.USA), lot number 053K1569; citric acid (Chengdu Honghe Chemical Reagent Factory), lot number: 20040821. Insulin kit (Shanghai Xitang Biotechnology Co., Ltd.). The blood glucose detector is the Llifscan product of Johnson & Johnson and supporting test strips.

[0037] 2. Divide 40 mice into 2 groups on average, 20 in each group...

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Abstract

The invention discloses a new application of thymosin Alpha 1, which relates to the thymosin Alpha 1 and provides a new application of the thymosin Alpha 1. The thymosin Alpha 1 is used for preparing diabetes medicines. By the verification of animal experiments, the thymosin Alpha 1 can not only slow down the weight increase of a mouse, lower the normal fasting blood sugar of the mouse and obviously enhance the sugar tolerance of the mouse, but also prevent STZ from inducing the occurrence of diabetes of the mouse; besides, the thymosin Alpha 1 also plays an important role in protecting the structure of islet cells and the secretion level of insulin. The thymosin Alpha 1 can be used for maintaining normal glycometabolism and protecting the structure and functions of islet cells; by adopting the method of taking the thymosin Alpha 1 orally, the effect of obviously slowing down weight increase can be realized; therefore, the thymosin Alpha 1 can be applied to preparing drugs for preventing diabetes from occurring and treating diabetes and clinical practice.

Description

technical field [0001] The present invention relates to Thymosin α1 (Thymosin α1, Tα1), especially relates to a new application of Thymosin α1. Background technique [0002] The clinical application of thymosin began in the mid-1970s, and its most important contribution was the treatment of thymus-dependent diseases. Because it maintains the immune reactivity of patients with primary immunodeficiency diseases, autoimmune diseases and cancer, it stimulates its The activity of specific lymphocytes plays a major role, so it is widely used in the treatment of diseases such as systemic lupus erythematosus, Behcet's syndrome, rheumatoid arthritis, severe infection, bronchial asthma, acute and chronic hepatitis, and tumors. In addition, since human aging obviously reflects the atrophy and failure of thymus tissue, thymosin can delay the appearance of some senile diseases, so the application of thymosin for anti-aging also has a very broad prospect. [0003] With the deepening of r...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P3/10
Inventor 周克夫王世媛韩伟吴汉州刘升发
Owner XIAMEN UNIV
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