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Medicine for treating chicken pox and preparation method thereof

A chickenpox and drug technology, applied in the direction of antiviral agents, antibodies, etc., can solve problems such as drugs that have not seen chickenpox, and achieve the effects of high yield and purity, high virus safety, and good quality

Inactive Publication Date: 2009-02-11
SICHUAN YUANDASHUYANG PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are no relevant reports on drugs that can effectively treat chickenpox

Method used

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  • Medicine for treating chicken pox and preparation method thereof
  • Medicine for treating chicken pox and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The preparation of embodiment 1 varicella human immunoglobulin

[0047] 1. Use 0.5ml / cartridge freeze-dried varicella live attenuated vaccine produced by Changchun Institute of Biological Products of China National Biological Products Corporation to immunize blood donors. Three months later, blood donors were given booster immunization injections again.

[0048] 2. Collect plasma from blood donors 3 months after booster immunization injection, and measure the varicella virus antibody titer in the plasma. The plasma with varicella virus antibody titer ≥ 8U / ml is qualified plasma.

[0049] 3. Before production, each bag of plasma should be rechecked with diagnostic reagents approved by the state for infectious pathogenic microbial markers such as hepatitis B surface antigen (HBsAg), HCV antibody, HIV (1+2) antibody, syphilis, ALT, etc. The results should be is negative. Eliminate unqualified plasma and strictly prevent cross-contamination between unqualified plasma bags...

Embodiment 2

[0060] Example 2 Preparation of Intravenous Injection of Varicella Human Immunoglobulin

[0061] The varicella human immunoglobulin stock solution prepared in Example 1 was used to prepare an intravenous injection so that the IgG content in the intravenous injection was not less than 50 g / L and the varicella antibody titer was not less than 50 IU / ml, and maltose was added to 10%.

[0062] It is sub-packaged in a 10,000-level local 100-level clean room. Each bottle is divided into 2000IU (50IU / ml, 40ml) / bottle, containing 2000IU of human blood-derived varicella antibody, the potency is not less than 50IU / ml, and the volume is 40ml.

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Abstract

The invention relates to a drug for treating chicken pox and a preparation method thereof, pertaining to the field of blood products. The technical problem solved by the invention is that: a drug which can effectively treat chicken pox is provided. The drug for treating chicken pox is a preparation which is prepared by adopting a chicken pox human immune globulin as a main active ingredient and adding with accessories acceptable in pharmacy, wherein, the chicken pox human immune globulin is prepared by adopting blood plasma obtained after a varicella vaccine is used for immunizing human bodies as raw material. The drug for treating chicken pox can be used for treating or preventing cytomegalovirus diseases and has wide application prospect.

Description

technical field [0001] The invention relates to a medicine for treating chickenpox and a preparation method thereof, belonging to the field of blood products. Background technique [0002] Varicella-zoster is a disease caused by varicella-zoster virus (varicella-zoster virus, VZV) infection. VZV infection is a common disease in childhood, can be transmitted through respiratory secretions, and is highly contagious. Healthy children are mostly infected with mild symptoms, but in some special populations such as immunocompromised persons, it can lead to disseminated infection with abnormally large skin lesions, secondary infection of opportunistic pathogenic bacteria such as group A streptococcus and Staphylococcus aureus, and Complications such as lung, brain, liver, kidney, heart, eye and other organ injuries, and even death. [0003] With the process of organ transplantation and the aging of the social population, VZV infection will be very common, and it is also a problem...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61P31/22
Inventor 魏宪义
Owner SICHUAN YUANDASHUYANG PHARM CO LTD
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