DNA chip for diagnosis of corneal dystrophy

A DNA chip, malnutrition technology, applied in the field of oligonucleotides, can solve problems such as visual loss
CN101374850AInactive Publication Date: 2009-02-25MEDIGENES CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
MEDIGENES CO LTD
Publication Date
2009-02-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to oligonucleotides for diagnosis of corneal dystrophy. More particularly, the present invention relates to oligonucleotides for detecting mutation of BIGH3 gene for diagnosis of corneal dystrophy including Avelllino corneal dystrophy, which must be precisely diagnosed before vision correction surgery, and a DNA chip for diagnosis of corneal dystrophy, which has the oligonucleotides fixed thereon. According to the present invention, conventional microscopic diagnosis of corneal dystrophy can be replaced with a precise genetic method, which prevents a patient with corneal dystrophy from losing eyesight by eyesight correction surgery after erroneous diagnosis.
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Description

technical field

[0001] The present invention relates to oligonucleotides useful in the diagnosis of corneal dystrophies. In particular, the invention relates to oligonucleotides for the detection of mutations in the BIGH3 gene for the diagnosis of corneal dystrophies, including Avelllino corneal dystrophy, which must be accurately diagnosed prior to vision corrective surgery, and to A DNA chip for diagnosing corneal dystrophy, having oligonucleotides immobilized thereon. Background technique

[0002] Corneal dystrophies are autosomal dominant disorders that begin with vague symptoms in the center of the cornea and spread gradually, so that eventually vision loss occurs as patients age. This disease includes Avellino corneal dystrophy, granular (Granular) corneal dystrophy, lattice (Lattice) type I corneal dystrophy, Reis-bucklers (Reis-bucklers) corneal dystrophy, etc., and is coded by βIG- Caused by mutations in the H3 gene.

[0003] Heterozygous patients afflicted with ...

Claims

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