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Yisheng granules and preparation method thereof

A technology of granules and prescriptions, which is applied in the field of medicine, can solve the problems of inaccurate curative effect and low bioavailability, and achieve definite curative effect, simple preparation process and good therapeutic effect

Active Publication Date: 2009-03-11
上海药正医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many preparations for the treatment of chronic pelvic inflammatory disease in the prior art, but most of them have low bioavailability and indefinite curative effect

Method used

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  • Yisheng granules and preparation method thereof
  • Yisheng granules and preparation method thereof
  • Yisheng granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take tangerine peel, dandelion, angelica, Bupleurum and add 12 times the amount of water, soak for 2 hours, steam distillation for 6 hours to extract the volatile oil, the distilled aqueous solution is collected in a separate container, and the dregs of the medicine are mixed with the rest of Astragalus, Scutellaria, Coix Seed 3. Toosendan is decocted twice with water, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1.5 hours, combine the decoction, filter, and the filtrate is the same as the above Combine the aqueous solutions, concentrate to a clear paste with a relative density of 1.05-1.10 (60°C), add ethanol to make the alcohol content 60%, refrigerate for 24 hours, filter, recover ethanol from the filtrate under reduced pressure and concentrate to a relative density of 1.05-1.10 (60°C) clear cream is collected in another device. The remaining Radix Paeoniae Alba, Radix Paeoniae...

Embodiment 2

[0016] Pharmacodynamics Test of Yisheng Granules

[0017] 1. In vitro antibacterial test

[0018] 1.1 Preparation of bacteria liquid: take a single colony on the common agar slant medium of 4 test strains of Escherichia coli, Staphylococcus aureus, Candida albicans and Pseudomonas aeruginosa, and inoculate them in 10ml broth culture medium for 16 hours at 37°C After that, dilute it with sterile physiological saline to a concentration of 1.5×108cfu / ml for later use.

[0019] 1.2 Determination of the minimum inhibitory concentration (MIC): Take several small test tubes containing 1ml broth medium, dilute the drug into a series of concentrations according to the two-fold dilution method, and then add the dilutions of each bacterial strain (all diluted to 10 Use after -4) 50 μl, mix well, incubate at 37°C for 24 hours, record the minimum liquid concentration of the test tube clarification, which is the minimum inhibitory concentration, the results are shown in Table 1.

[0020] ...

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PUM

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Abstract

The invention belongs to the medicine technical field and discloses yisheng particles and a preparation method thereof. The particles comprises the following components: 100-300g of white paeony root, 100-300g of red peony, 150-400g of rhizoma corydalis, 150-400g of viscum album, 150-400g of field pennycress, 150-400g of milk veteh, 100-300g of radix scutellariae, 150-400g of coix seed, 100-300g of fructus meliae toosendan, 100-300g of dried orange peel, 100-300g of angelica, 100-300g of radix bupleuri, 100-300g of dandelion. The preparation method is as follows: after part of drug ingredients are used for extracting volatile oil; dregs and other drug ingredients are blended by water extract-alcohol precipitation to prepare extract, the mixture is added with excipients to prepare particles. The test result of bacteriostasis, anti-inflammation, analgesic, immunoregulation and promoting blood circulation by removing blood stasis in vitro and in vivo shows that the particles of the yisheng particles has the functions of bacteriostasis, anti-inflammation, promoting blood circulation by removing blood stasis, analgesic and immunoregulation, and can better cure chronic pelvic inflammation.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, relates to a barley granule and a preparation method thereof, and also relates to the application of the barley granule in treating chronic pelvic inflammatory disease. Background technique: [0002] Pelvic inflammatory disease is a relatively common gynecological disease. It is the disease with the highest incidence rate of endangering women's health among obstetrical diseases, especially in rural women, which greatly affects women's labor productivity. Chronic pelvic inflammatory disease refers to the chronic inflammation of the female genitalia, its parauterine connective tissue, and pelvic inflammatory membrane. It is a common disease that seriously endangers women's health, frequently-occurring, and recurrent, lingering and difficult to heal. Staphylococcus, hemolytic streptococcus and Escherichia coli are the main pathogenic bacteria of pelvic inflammatory disease, and the pathogens are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61K9/16A61P15/00
Inventor 张国刚田宏
Owner 上海药正医药科技有限公司
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