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Pazufloxacin mesylate and preparation method of powder for injection

A technology for pazufloxacin mesylate and pazufloxacin, which is applied in the field of medicine, can solve the problems of difficulty in realization, low yield, and difficulty in fully reacting pazufloxacin, thereby reducing production time and production. cost, the effect of improving product quality

Inactive Publication Date: 2010-08-18
HAINAN YONGTIAN PHARMA INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the addition of methanesulfonic acid and pazufloxacin is relatively small, so it is difficult to fully react pazufloxacin; after the reflux reaction, it is difficult to directly cool and crystallize, and it will not be completely precipitated even for 40 hours. , so this synthetic method yields a low

Method used

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  • Pazufloxacin mesylate and preparation method of powder for injection
  • Pazufloxacin mesylate and preparation method of powder for injection
  • Pazufloxacin mesylate and preparation method of powder for injection

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Abstract

The invention discloses a method for preparing pazufloxacin mesilate and a powder injection thereof. The method is as follows: a reaction system which is formed by pazufloxacin and methane-sulforic acid as well as a solvent of acetone is subjected to heating and reflux, cooling and crystallization, and separation to obtain the pazufloxacin mesilate, and the pazufloxacin mesilate is then subjectedto aseptic filling and freeze drying to obtain the powder injection of pazufloxacin mesilate. The preparation method of the invention can produce pazufloxacin mesilate for injection which has stable quality.

Description

technical field The invention relates to a preparation method of pazufloxacin mesylate, in particular to a preparation method of pazufloxacin mesylate powder for injection, which belongs to the technical field of medicine. Background technique Pazufloxacin mesilate belongs to the fourth generation of quinolone anti-infective drugs. It was created by Toyama Co., Ltd. and jointly developed by Toyama Chemical Industry Co., Ltd. and Mitsubishi Corporation. Its side effects are significantly lower than similar varieties. In vitro antibacterial effect shows: against G-bacteria, the antibacterial activity is greater than ofloxacin, ciprofloxacin, sparfloxacin (2 to 4 times greater than ofloxacin), against G+ bacteria, the antibacterial activity of this product is the same as that of Similar to ofloxacin. The antibacterial effect in vivo shows that it has a good curative effect on mouse models infected with G+ bacteria and G- bacteria, including quinolone-resistant Serratia marcesc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D498/06A61K31/5365A61K9/14A61P31/04
Inventor 王明
Owner HAINAN YONGTIAN PHARMA INST
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