Fluorescent molecule tomography rebuilding method based on linear relationship

A technology of fluorescence molecular tomography and linear relationship, which can be used in fluorescence/phosphorescence, 2D image generation, diagnosis, etc., and can solve problems such as improving method calculation speed
CN101396262AInactive Publication Date: 2009-04-01TSINGHUA UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TSINGHUA UNIV
Publication Date
2009-04-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

A tomography reconstruction method of fluorescence molecules based on a linearity relation belongs to the technical field of the image reconstruction in biomedicine. The reconstruction method is characterized in that the method sequentially comprises the following steps: 1. the outside surface outline is obtained by picture processing and numerical fitting based on the map data of a mouse used in experiment; 2. the outside surface outline is led into a finite element software package for meshing; 3. every excitation light source, and finite element grid nodes which are corresponding to corresponding fluorescence monitoring points are found; 4. aiming at one given excitation light source sk, a linear relation matrix Wsk between fluorescence intensity which is detected from surface and unknown fluorescent probe distribution is established; 5. aiming at all excitation light sources, a general linear relation matrix is generated; 6. after the linear relation is obtained, a algebra reconstruction method is used for iterating the fluorescent probe distribution which approaches the reality. The method is characterized in that non-uniform optical parameters can be handled and the precise linear relation between the fluorescence intensity which is detected from surface and the unknown fluorescent probe distribution is rapidly established.
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Description

technical field

[0001] The invention belongs to the technical field of image reconstruction in biomedicine, and relates to a three-dimensional image reconstruction method. Background technique

[0002] Molecular imaging is a hot direction in the field of biomedicine in recent years. Molecular imaging can be broadly defined as the qualitative and quantitative measurement of biological processes in vivo at the molecular and cellular levels [R. Weissleder, Radiology, 2001]. Fluorescence molecular tomography (FMT) is an important aspect in molecular imaging. It is widely used in biological and medical research fields, making fluorescent molecular imaging from a qualitative biopsy tool to a tool that can be used for accurate, 3-dimensional imaging.

[0003] The key to fluorescence molecular tomography is to obtain projection data from multiple angles for reconstruction. Different from equipment based on high-energy rays such as CT, the propagation of light (400nm-900nm) in bio...

Claims

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