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Fluorescent molecule tomography rebuilding method based on linear relationship

A technology of fluorescence molecular tomography and linear relationship, which can be used in fluorescence/phosphorescence, 2D image generation, diagnosis, etc., and can solve problems such as improving method calculation speed

Inactive Publication Date: 2009-04-01
TSINGHUA UNIV
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Problems solved by technology

However, in the process of calculating the linear relationship, there are operations for inverting large-scale sparse matrices, which limit the further improvement of the calculation speed of the method

Method used

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  • Fluorescent molecule tomography rebuilding method based on linear relationship
  • Fluorescent molecule tomography rebuilding method based on linear relationship
  • Fluorescent molecule tomography rebuilding method based on linear relationship

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Embodiment Construction

[0081] The mechanism of fluorescent molecular imaging can be used figure 1 Description: The excitation light emitted by the excitation light source excites the fluorescent probes (labeled proteins, tumors, fluorescent dyes, etc.) in the tissue to emit fluorescence, and the fluorescence transmitted to the surface is detected by the CCD camera. exist figure 1 , at position r sThe excitation light emitted by the point light source propagates in the experimental mouse body, indicated by the solid arrow. After the excitation light encounters the fluorescent probe, it will be absorbed by the fluorescent probe, and then the fluorescent probe will be excited to emit fluorescence with a higher wavelength. Fluorescence propagation in experimental mice is indicated by dashed arrows. Fluorescence reaching the surface of the experimental mouse opposite to the excitation light source can be detected with a CCD camera. There is a fluorescence filter in front of the CCD camera to ensure t...

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Abstract

A tomography reconstruction method of fluorescence molecules based on a linearity relation belongs to the technical field of the image reconstruction in biomedicine. The reconstruction method is characterized in that the method sequentially comprises the following steps: 1. the outside surface outline is obtained by picture processing and numerical fitting based on the map data of a mouse used in experiment; 2. the outside surface outline is led into a finite element software package for meshing; 3. every excitation light source, and finite element grid nodes which are corresponding to corresponding fluorescence monitoring points are found; 4. aiming at one given excitation light source sk, a linear relation matrix Wsk between fluorescence intensity which is detected from surface and unknown fluorescent probe distribution is established; 5. aiming at all excitation light sources, a general linear relation matrix is generated; 6. after the linear relation is obtained, a algebra reconstruction method is used for iterating the fluorescent probe distribution which approaches the reality. The method is characterized in that non-uniform optical parameters can be handled and the precise linear relation between the fluorescence intensity which is detected from surface and the unknown fluorescent probe distribution is rapidly established.

Description

technical field [0001] The invention belongs to the technical field of image reconstruction in biomedicine, and relates to a three-dimensional image reconstruction method. Background technique [0002] Molecular imaging is a hot direction in the field of biomedicine in recent years. Molecular imaging can be broadly defined as the qualitative and quantitative measurement of biological processes in vivo at the molecular and cellular levels [R. Weissleder, Radiology, 2001]. Fluorescence molecular tomography (FMT) is an important aspect in molecular imaging. It is widely used in biological and medical research fields, making fluorescent molecular imaging from a qualitative biopsy tool to a tool that can be used for accurate, 3-dimensional imaging. [0003] The key to fluorescence molecular tomography is to obtain projection data from multiple angles for reconstruction. Different from equipment based on high-energy rays such as CT, the propagation of light (400nm-900nm) in bio...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00G01N21/64G06T7/00G06T7/10G06T11/00
Inventor 白净汪待发金燕陈延平王洪凯刘欣陈欣潇李明泽
Owner TSINGHUA UNIV
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