Compositions and methods for preserving brain function

A composition and functional technology, applied in the direction of drug combination, function and application of food ingredients, etc., can solve problems such as loss of urination control or defecation control, getting lost or confused, and reduced daytime activities

Active Publication Date: 2009-04-08
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, they may not respond to their names or familiar commands, may become lost or confused in familiar surroundings, may no longer welcome or respond to their owners or guests, may show decreased daytime activity, may wander around Walking in circles, possible emotional avoidance, and possible loss of urinary or bowel control

Method used

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  • Compositions and methods for preserving brain function
  • Compositions and methods for preserving brain function
  • Compositions and methods for preserving brain function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0203] animals and diet

[0204] Fifty-four animals aged 8-11 years were divided into three cognitively equal treatment groups using error-criteria based on object discrimination and reverse learning tests (Table 1). The animals did not show any pathological signs and were considered healthy geriatric dogs. The first group, the control group, was fed a basal diet consisting of approximately 10% water, 26% crude protein, 16% fat, and 6% ash without MCT supplementation. The basal diet consists of ingredients commonly used in companion animal diets such as brewer's rice, chicken, whole wheat, poultry by-product diet, corn gluten diet, corn kernels, animal fat, corn bran, dried egg products, flavor enhancers, vitamins and minerals. The MCTs administered to the animals in these experiments had the following general formula:

[0205]

[0206] Among them, in these applications, more than 95% of R1, R2 and R3 are fatty acids containing 8 carbon atoms in the carbon backbone and...

Embodiment 2

[0217] blood analysis

[0218] Hematology and biochemical tests of blood were performed at baseline on day 9 and approximately every 30 days until the animal completed cognitive testing. Blood chemistry and hematology are monitored as an index of general health and as a measure of the animal's response to treatment. Collect and save other serum and plasma samples. Animals did not all receive the same number of blood samples because animals did not complete the study at the same rate. Therefore, only hematological and biochemical data obtained on study days 0 (T0), 9 (T1), 39 (T2), 69 (T3), 99 (T4) and 129 (T5) were included in this analysis middle.

[0219] Between-subjects variable by treatment group (0 g / kg / day vs. 1 g / kg / day vs. 2 g / kg / day) and time point (T0 vs. T1 vs. T2 vs. T3 vs. T4 vs. T5) Within variables, various blood measurements were analyzed using independent repeated measures ANCOVA. Group (1 vs 2 vs 3) was used as covariate.

[0220] The blood measureme...

Embodiment 3

[0228] Analysis of treatment impact on dog activity and behavior

[0229] Activity Analysis: Using Activity monitoring systems measure activity rhythms. Activity counts were recorded every 30 seconds for 3 days. Average activity levels were calculated from these data for two time periods: (1) sunset to sunrise (night), and (2) sunrise to sunset (day). In addition, the average lag between sunrise and the onset of activity (defined as 30-min activity) was calculated for each animal, where a negative score indicates that activity occurred before sunrise.

[0230] Behavioral Analysis: Two separate experiments were conducted to evaluate changes in spontaneous, exploratory, and social behavior: a curiosity experiment and an interaction experiment. The trial was performed twice: once before the onset of treatment (baseline) and once after about 2 months of treatment. Spontaneous behaviors quantitatively included: total locomotor activity, urination, sniffing, frequency and dura...

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Abstract

Compositions and methods for preventing, reducing, or delaying decline in one or more of cognitive function, motor function, cerebrovascular function, or behavior in animals, particularly geriatric animals, are disclosed. The compositions and methods utilize medium chain triglycerides.

Description

technical field [0001] The present invention relates to mammalian nutrition and its effects on cognitive function, behavior and brain physiology. In particular, the present invention utilizes medium chain triglycerides administered as part of a long-term dietary regimen to preserve or improve learning, attention, exercise capacity, cerebrovascular function, social behavior and enhance activity levels, particularly in aging animals middle. Background of the invention [0002] Various publications are cited throughout this specification, including patents, published applications, technical literature, and academic papers. These cited publications are hereby incorporated by reference in their entirety. All citations to publications that are not cited in their entirety in this specification are set forth at the end of this specification. [0003] Cognitive impairment, progressive decline in cognitive function, changes in brain morphology, and changes in cerebrovascular functi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P25/28A61K31/19A61K31/205A61K31/215A61K31/22A23L1/29A23L33/00
CPCA23V2002/00A61K31/19A61K31/205A61K31/215A23L1/3006A61K31/22A23L33/115A61P1/16A61P25/00A61P25/14A61P25/28A61P9/10A23V2200/322A23V2250/1944
Inventor B·T·拉尔森S·T·亨德森M·A·罗伯茨
Owner SOC DES PROD NESTLE SA
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