Chinese medicine granular containing ginseng extract and preparation method thereof

A technology for extracting traditional Chinese medicine granules and ginseng, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, drug combinations, etc., can solve problems such as lack of immediate release characteristics, low drug loading of granules, and unsightly appearance, and achieve physical Good characteristics, good particle fluidity, and short dissolution time

Inactive Publication Date: 2009-05-27
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] 1. Get 300 g of ginsenosides produced by Hongjiu Biotechnology Co., Ltd., and through high-performance liquid phase (HPLC) determination, 24 g of ginsenosides Rh 2 , get another 2700g ginseng polysaccharide, mix well, and prepare the active ingredient of the present invention.

[0049] 2. Preparation of masterbatch

[0050] Take the above-mentioned clathrate through a 100-mesh sieve, put 50wt% into the side spray pot of the fluidized bed, add water to the PVP K30 containing 10wt% clathrate to prepare a binder solution (5%, g / ml) as a slurry spray and sieve out small particles (120-180μm) as the mother nucleus, then put the mother nucleus into the pot, continue to spray the slurry, and at the same time spray the remaining clathrate from the powder gun to make the mother nucleus The particle size grows up, and the masterbatch with a particle size of 200-300 μm is screened out for use.

[0051] 3. Selection of viscosity modifier

[0052] a. Dilute the above-mentioned ex...

Embodiment 2

[0062] Preparation of the active ingredient of the present invention: Take 60g of ginsenosides produced by Hongjiu Biotechnology Co., Ltd., and measure through high performance liquid phase (HPLC), which contains 30g of ginsenosides Rh 2 , get 299.4g ginseng polysaccharide in addition, mix, make active ingredient of the present invention.

[0063] Preparation of masterbatch: Take a mixture of micropowder silica gel and chitosan with a weight ratio of 1:1 to pass through a 200-mesh sieve, 65% of which is used as the base material and put into the side spray pot of the fluidized bed, and another PVP K30 is added with water, extract, and prepared Adhesive forming agent-spray in as slurry, and sieve out small particles with a particle size of 120-180μ as the mother nucleus, then put the mother nucleus into the pot, continue to spray starch slurry, and at the same time, spray the remaining 35% from the powder gun The fine powder of micronized silica gel and chitosan is sprinkled in...

Embodiment 3

[0066] The preparation of active ingredient of the present invention: get 90g of ginsenosides produced by Huizhou Dongfang Plant Health Technology Co., Ltd., and measure through high-performance liquid phase (HPLC), wherein contain 6g ginsenoside Rh 2 , get 358g ginseng polysaccharide in addition, mix, make active ingredient of the present invention.

[0067] Preparation of masterbatch: take a mixture of dextrin and starch with a weight ratio of 1:1 and pass through a 200-mesh sieve, 65% of which is put into the side spray pot of the fluidized bed as the bottom material, and starch and extract (after being folded and dried to account for the mother batch) 15% of the grain weight) and water to make a slurry and spray it in, and sieve out small particles (180-250μ) as the mother nucleus, then put the mother nucleus into the pot, continue to spray the starch slurry, and at the same time, spray it from the powder gun Sprinkle the remaining 35% dextrin and starch fine powder to mak...

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Abstract

The invention provides a traditional Chinese medicine granular preparation with ginseng extract and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using a traditional Chinese medicine extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g / ml to 1.3 g / ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing ginseng extract and a preparation method thereof. Background technique [0002] Ginseng is Araliaceae Panax ginseng C.A. Meyer. As early as two thousand years ago, our ancestors discovered and used ginseng to prevent and treat diseases. Chinese people also have the habit of taking ginseng supplements, and doctors of all dynasties said that it has the power of "replenishing vitality". my country's earliest pharmacy classic "Shen Nong's Materia Medica" stated that ginseng "mainly nourishes the five internal organs, calms the spirit, calms the soul, relieves panic, improves eyesight and improves intelligence, long-term use makes light of body and prolongs life." Later, in "Famous Doctors", "Treatise on Febrile Diseases ", "Tang Materia Medica" and "Compendium of Materia Medica" and other m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K9/16A61P35/00A61P37/04
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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