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Pharmaceutical composition

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, anhydride/acid/halide active ingredients, etc., to achieve stable and reliable duration, stable and reliable volume effect effect

Active Publication Date: 2009-06-03
HANGZHOU MINSHENG PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The Chinese patent "200610091185.7 A pharmaceutical composition for expanding blood volume and its preparation method" mentions that the pharmaceutical composition does not contain calcium, but the prescription contains magnesium ions. The reason is that it is not the case in clinical use due to incompatibility. , because the range of incompatibility between magnesium and calcium ions and other drugs is roughly the same, the incompatibility problems encountered by calcium ions, magnesium ions will also encounter

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] prescription:

[0041] Sodium ion 130mmol / L

[0042] Potassium ion 5.5mmol / L

[0043] Calcium ion 1.0mmol / L

[0044] Magnesium ion 1.0mmol / L

[0045] Chloride ion 112.5mmol / L

[0046] Acetate ion 27mmol / L

[0047] Hydroxyethyl starch 60g / L

[0048] Preparation:

[0049] Pour water for injection into a stirring container, add 60g of hydroxyethyl starch 200 / 0.5, heat and stir to make it fully dissolved, then add 6.34g of sodium chloride, 0.41g of potassium chloride, and 0.147g of calcium chloride dihydrate, Magnesium chloride hexahydrate 0.203g, sodium acetate trihydrate 3.67g, and stir to dissolve, add water for injection to dilute to 1000ml, add appropriate amount of activated carbon, stir, boil, keep warm for 20 minutes, then filter with titanium rod, 0.45 micron microporous membrane, pour Pack it, sterilize it at high temperature, and get ready.

Embodiment 2

[0051] prescription:

[0052] Sodium ion 130.7mmol / L

[0053] Potassium ion 4mmol / L

[0054] Calcium ion 1.0mmol / L

[0055] Chloride ion 108.7mmol / L

[0056] Acetate ion 28mmol / L

[0057] Hydroxyethyl starch 60g / L

[0058] Preparation:

[0059] Pour water for injection into a stirring container, add 60g of hydroxyethyl starch 200 / 0.5, heat and stir to dissolve it fully, then add 6g of sodium chloride, 0.3g of potassium chloride, 0.2g of calcium chloride dihydrate, three Sodium acetate in water 3.8g, stirred and dissolved, diluted with water for injection to 1000ml, added appropriate amount of activated carbon, stirred, boiled, kept warm for 20 minutes, then successively filtered with titanium rod, 0.45 micron microporous membrane, filled, high temperature sterilized, namely Can.

Embodiment 3

[0061] prescription:

[0062] Sodium ion 130mmol / L

[0063] Potassium ion 5.5mmol / L

[0064] Calcium ion 1.0mmol / L

[0065] Magnesium ion 1.0mmol / L

[0066] Chloride ion 112.5mmol / L

[0067] Acetate ion 27mmol / L

[0068] Glucose 0.99g / L

[0069] Hydroxyethyl starch 60g / L

[0070] Preparation:

[0071] Pour water for injection into a stirring container, add 60g of hydroxyethyl starch 200 / 0.5, heat and stir to make it fully dissolved, then add 6.34g of sodium chloride, 0.41g of potassium chloride, and 0.147g of calcium chloride dihydrate, Magnesium chloride hexahydrate 0.203g, sodium acetate trihydrate 3.67g, glucose 0.99g and stir to dissolve, add water for injection to dilute to 1000ml, add appropriate amount of activated carbon, stir, boil, keep warm for 20 minutes, and then use titanium rod, 0.45 micron microporous membrane in turn Filtration, filling, high-temperature sterilization, that is.

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Abstract

The invention provides a pharmaceutical composition for expanding blood volume. The composition contains hydroxyethyl group starch and an electrolyte component. Content of components in the pharmaceutical composition is as follows: 55-65g / L of hydroxyethyl group starch 200 / 0.5, 120-145mmol / L of sodion, 3.5-5.5mmol / L of potassium ion, 1.0-3.5mmol / L of calcium ion, 96-125mmol / L of chloridion and 27-50mmol / L of acetate ion, and the pharmaceutical composition contains 0.7-1.25mmol / L of magnesian ion or does not contain the magnesian ion and contains 0.99g / L of glucose does not contain the glucose. The hydroxyethyl group starch is the hydroxyethyl group starch 200 / 0.5, the weight-average molecular weight of the hydroxyethyl group starch 200 / 0.5 ranges from 175,000 dalton to 225,000 dalton, and the mol substituted ratio of the hydroxyethyl group starch 200 / 0.5 ranges from 0.43 to 0.55.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition containing hydroxyethyl starch 200 / 0.5 and electrolyte balance liquid, and belongs to the field of pharmaceutical preparations. Background technique [0002] Hypovolemia is a common problem in surgical patients during the perioperative period, so it is very important to choose the appropriate type of fluid for safe and effective volume therapy. Crystalloids, colloids, and whole blood are used clinically for volume supplementation. In recent years, artificial colloids have been widely used. The commonly used ones are dextran, hydroxyethyl starch, gelatin, etc. In recent years, due to the expansion effect and safety of hydroxyethyl starch, it is the most ideal among various artificial colloids, and it has gradually become the most ideal. Widely used plasma expander. my country began to use hydroxyethyl starch 706 generation plasma (HES40 / 0.9) in the 197...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K33/14A61K31/19A61P7/08
Inventor 陈光荣周娜俞伯根张竹林吴春霞
Owner HANGZHOU MINSHENG PHARM CO LTD
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