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Double sustained release biological agent for tumor local ablation therapy

A dual sustained-release, biological preparation technology is applied in the technical field of biological drugs, and achieves the effects of avoiding toxic and side effects, being easy to operate, and reducing pain.

Inactive Publication Date: 2009-06-10
FUJIAN MEDICAL UNIV UNION HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the combined application of ricin and cobra venom cytotoxin for anti-tumor at home and abroad. The present invention adopts temperature-sensitive gel and PLGA microspheres to prepare its slow-release preparation, and cobra venom cytotoxin is wrapped in a slow-release period Long PLGA microspheres, and then embedded in a thermosensitive gel with ricin, provide a dual slow-release biologic for tumor local ablation therapy, guided by imaging techniques for accurate injection into tumor tissue Inner, easy to operate, low cost, safe and efficient, painless for patients, easy to accept

Method used

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  • Double sustained release biological agent for tumor local ablation therapy
  • Double sustained release biological agent for tumor local ablation therapy
  • Double sustained release biological agent for tumor local ablation therapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The double sustained-release biological preparation of this embodiment is used for the following injections against human liver cancer, breast cancer, prostate cancer nude mice or against mouse cervical cancer, melanoma, S180 sarcoma or for the treatment of rabbit orthotopic liver VX2 tumors or other tumors , the total amount of this formula is 7 ml, and the concentration of the selected temperature-sensitive gel is 20%. Contains norepinephrine 25μg, ricin 0.25μg, cobra venom cytotoxin 5μg.

Embodiment 2

[0043] The double sustained-release biological preparation of this embodiment is used for the following injections against human liver cancer, breast cancer, prostate cancer nude mice or against mouse cervical cancer, melanoma, S180 sarcoma or for the treatment of rabbit orthotopic liver VX2 tumors or other tumors , the total amount of this formula is 6 ml, and the concentration of the selected temperature-sensitive gel is 25%. Contains norepinephrine 50μg, ricin 0.5μg, cobra venom cytotoxin 10μg.

Embodiment 3

[0045] The double sustained-release biological preparation of this embodiment is used for the following injections against human liver cancer, breast cancer, prostate cancer nude mice or against mouse cervical cancer, melanoma, S180 sarcoma or for the treatment of rabbit orthotopic liver VX2 tumors or other tumors The total amount of this formula is 10 milliliters, and the concentration of the selected temperature-sensitive gel is 30%. The preparation method of this component is the same as the preparation method of the above-mentioned "5". The gel contains 75 μg of norepinephrine, 0.75 μg of ricin, and 15 μg of cobra venom cytotoxin.

[0046]The total amount of the dual sustained-release biological formulations in the above examples can be taken as needed, that is, it can be prepared according to the required amount for injecting anti-human liver cancer nude mice or treating rabbit orthotopic liver VX2 tumors or other tumors.

[0047] 8. Acute Toxicity Test of Dual Sustained-...

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Abstract

The invention discloses a dual slow release biological preparation for tumor local ablation therapy, which comprises temperature sensing type gel, ricin, noradrenalin and poison microsphere carried with cobra venom cell and is made by the temperature sensing type gel packaging the noradrenalin, the ricin and the poison microsphere carried with cobra venom cell. The concentration of the temperature sensing type gel is 15-45, the temperature sensing type gel with concentration of 15-4501AF3450er ml contains the noradrenalin 10-100 mu g, the ricin 0. 1-1 mu g, the poison microsphere carried with cobra venom cell 2-20 mu g. The invention can be injected into the a nude mice tumor tissue of human hepatocellular carcinoma or can be injected with rabbit home position liver tumor VX2 under ultrasonic guiding in experiment, the invention has obvious anti-tumor effect, can be applied for local ablation therapy of human liver, kidney, pancreas, spleen, prostate gland, uterus, ovary, retroperitoneal and superficial soft tissue tumors under ultrasonic wave or CT guiding.

Description

Technical field: [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to a dual slow-release biological preparation for local tumor ablation therapy. Release agent, so that it can be applied to the preparation of drugs for treating tumors, specifically for injection into tumor tissues guided by imaging technology, so as to achieve the purpose of completely inactivating tumors with low systemic toxic and side effects, and is safe and efficient. Background technique: [0002] Tumor is a new organism formed by abnormal proliferation of cells in local tissues due to the loss of normal regulation of its growth at the gene level under the action of various tumorigenic factors. It is a common disease and frequently-occurring disease. According to the biological characteristics of tumors and their different harmfulness to the body, they are generally divided into two categories: benign tumors and malignant tumors, among which malignant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K38/16A61K38/17A61K31/137A61K47/34A61P35/00
Inventor 林礼务陈志奎薛恩生杨发端林晓东何以敉高上达
Owner FUJIAN MEDICAL UNIV UNION HOSPITAL
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