17 results about "Soft tissues tumors" patented technology

The present invention discloses a soft tissue tumor puncture biopsy needle device, including a needle tube, a needle handle and a driving unit. A cylinder cavity is provided inside the needle handle; the proximal end of the needle tube is connected to the needle handle and the internal channel of the needle tube is connected to the cylinder cavity; a piston is slidably connected in the cylinder cavity, a driving structure is installed on the needle handle, and the output end of the driving unit is connected to the piston, which is used to drive the piston to slide in the cylinder cavity; an exhaust port connected to the outside is also provided on the cylinder cavity, and a one-way valve that only allows gas to flow from the cylinder cavity to the outside is provided on the exhaust port. The soft tissue tumor puncture biopsy needle device provided by the present invention can continuously draw the target object into the internal channel of the needle tube without the need for multiple punctures, and at the same time, it is not necessary to leave a safe distance like a cutting needle.

The invention relates to a rearrangement driven solid tumor fusion gene detection reagent, a kit and a detection system, belongs to the technical field of biological medicines, and provides a detection probe library, a detection reagent, a detection kit and a detection system for detecting a human solid tumor fusion gene. Probes in the probe library can be hybridized with one or more chromosome sites, and the total number of the sites is 11472; the detected solid tumors comprise rearrangement-driven solid tumors such as soft tissue tumors, uterine mesenchymal tumors or salivary gland tumors. The target RNA fusion gene detection reagent provided by the invention can be used for fusion gene detection at the RNA level, and has more advantages in the aspect of detection capability. The important significance is realized on the auxiliary diagnosis of solid tumors; according to the invention, multiple gene fusion forms can be detected at the same time, accurate diagnosis and treatment opportunities are provided for patients, and economic burden and additional risks caused by superposition of multiple markers are avoided.

The application relates to the technical field of medical auxiliary devices, in particular to an adjustable fixing support and method for positioning of a four-limb soft tissue tumor radiotherapy, which obtains a pressure displacement time sequence in an initial exploration stage, and filters out a bone support channel and a soft tissue channel based on calculated terminal tangent stiffness, so that an asymmetric fixing strategy can be used accordingly. By determining a bone locking displacement amount, a rigid reference is established on the bone side first, effectively blocking passive displacement of the bone to the soft tissue side; a soft tissue locking displacement amount determined based on effective change of pressure data of the soft tissue channel can quantitatively compensate for rheological properties of the soft tissue and resist stress relaxation. The asymmetric active locking and rheological compensation mechanism based on stiffness difference screening overcomes the problems of target area displacement caused by uneven force and fixing failure caused by tissue relaxation in the traditional symmetric clamping, so that the application has higher accuracy for positioning of four-limb soft tissue tumor radiotherapy.

This invention provides a needle for bone and soft tissue tumor biopsy, comprising a needle body, a ring-taking probe, and a pusher. The needle body includes an outer cannula and a core. A channel is formed through the inner part of the outer cannula. The core is inserted into and exits the channel during puncture. The two ends of the outer cannula are a first end and a second end, respectively. The two ends of the core are a third end and a fourth end, respectively. The third end is a needle tip that extends beyond the first end, and the fourth end is used to engage with the second end to form a handle. A depth fixation device is installed on the outer wall of the outer cannula for adsorption onto the tissue surface. The ring-taking probe is inserted into the channel of the outer cannula after the core is removed to extract tissue samples. The distal inner wall surface of the ring-taking probe has a barbed structure. The pusher is inserted into the outer cannula after sample extraction to completely push out any remaining tissue from the outer cannula. This invention can improve the accuracy and comfort of bone and soft tissue tumor biopsy, reduce the sampling failure rate during puncture, and increase the sample volume.

The embodiment of the invention discloses a bone soft tissue tumor repair prosthesis printing method based on a multi-agent decision-making system. The method comprises the following steps: generating tumor knowledge map information according to preset tumor grade screening information, preset tumor grading standard information, acquired tumor-related material information and tumor-related material information; performing change processing on the initialized preset tumor decision intelligent agents to obtain a tumor decision intelligent agent group; generating task processing distribution information according to preset tumor record information and the tumor decision agent group; according to the tumor decision intelligent agent group, the task processing distribution information and the tumor knowledge graph information, prosthesis printing reference information is generated; according to the prosthesis printing reference information, generating a tumor material reconstruction image; and according to the tumor material reconstruction image, controlling a printing device to print a tumor repair prosthesis. According to the implementation mode, the accuracy of the generated prosthesis printing reference information can be improved, and waste of biocompatible materials for 3D printing is reduced.

The invention belongs to the field of biological medicines, particularly provides a pharmaceutical composition containing an anti-CD47 antibody and a tyrosine kinase inhibitor for treating bone and soft tissue tumors, and further provides a kit containing the pharmaceutical composition. In addition, the use of the anti-CD47 antibody in the preparation of a medicament for the treatment of bone and soft tissue tumors in combination with a tyrosine kinase inhibitor and a method of treating bone and soft tissue tumors are provided.

The present invention relates to a conditionally replicating adenovirus having the E1A gene under expression control of a Survivin promoter, wherein the adenovirus is not defective inthe E3 region and a pharmaceutical composition for treating a bone and soft tissue tumor, containing the conditionally replicating adenovirus as an active ingredient.

The invention belongs to the technical field of intelligent medical assistance, and discloses an AR-based soft tissue tumor resection auxiliary planning method. By introducing a hybrid deep learning model based on SAMMMed and DeepSnake, high-precision tumor segmentation and boundary optimization are realized, and the problem of discontinuous soft tissue image boundaries is solved; a point cloud registration system combining rigid and non-rigid algorithms is constructed, and dynamic alignment and real-time updating of a preoperative model and intra-operative scanning data are achieved; a visualization method based on volume rendering ray casting is adopted, a high-fidelity three-dimensional visualization effect is generated, and a doctor is helped to obtain clear spatial cognition in an operation; an optical navigation system and an augmented reality head display equipment coordinate system are uniformly fused, so that accurate correspondence of virtual-real superposition is realized, and the stability and accuracy of model display in an operation are ensured; a voice recognition and gesture interaction mechanism is introduced, non-contact operation is achieved, the sterile requirement of an operating room is met, and the operation naturalness and convenience are improved.

The present invention discloses a preparation method of a soft tissue tumor specimen incision fixator and its suction cup, including a storage box. One end of the storage box is open, and an adjustable-height grid tray is arranged inside the storage box. A groove is arranged on the inner wall of the storage box, and a connecting rod is vertically arranged inside the groove. The grid tray is provided with a connecting head at the groove. A round hole is arranged in the middle of the connecting head, and the connecting head is sleeved on the surface of the connecting rod through the round hole. A fastening ring is arranged at the connection between the connecting head and the connecting rod; a column is arranged on the upper surface of the storage box, and an adjusting rod rotatably connected thereto is arranged on the surface of the column. A suction cup is arranged at one end of the adjusting rod; the preparation method of the suction cup includes: mixing, kneading, open milling, primary vulcanization, and secondary vulcanization. The soft tissue tumor specimen incision fixator is provided with a liftable grid tray, and the suction cup can be adjusted under the action of the adjusting rod, so as to be applicable to soft tissue tumor specimens of different sizes and is convenient to use.

The utility model discloses a forehead soft tissue tumor resection endoscope cannula, which comprises a puncture cannula, the front end of the puncture cannula is provided with a spreader, the rear end of the puncture cannula is provided with an incision protection plate, and the incision protection plate and the axis of the puncture cannula form an included angle of 60 degrees. The dilator end of the endoscopic cannula is inserted into a skin incision, the front end of the puncture cannula is pushed to a to-be-cut tumor site, the puncture cannula is provided with a hollow instrument channel, the instrument channel is communicated with the front end of the puncture tube and the incision protection plate, and when the front end of the puncture cannula reaches the to-be-cut tumor site, the incision protection plate is adjusted to be parallel to the forehead face in the tangential direction, and the incision protection plate is pushed to the to-be-cut tumor site. The effect of protecting the skin incision is achieved. Meanwhile, surgical instruments such as an endoscope can be conveyed to the site where the tumor is to be cut through the instrument channel for surgical operation. The incision protection plate of the endoscope cannula can be effectively attached to the frontal face hairline position, an incision is effectively protected, and therefore implementation of a follow-up endoscope operation is more convenient, and the problems existing in the prior art are effectively solved.

1. Name of the design product: Disposable puncture biopsy needle. 2. Use of the design product: A disposable puncture biopsy needle for soft tissue and soft tissue tumor biopsy. 3. Design key points of the design product: Lies in the shape. 4. Picture or photo that best shows the design key points: Perspective view 1.

A method for treating a bone and soft tissue tumor, including administering a conditionally replicating adenovirus having a E1A gene under expression control of a Survivin promoter, to a subject in need thereof. A conditionally replicating adenovirus including a E1A gene under expression control of a Survivin promoter and the conditionally replicating adenovirus is not defective in a E3 region.

The invention discloses a soft tissue tumor needle biopsy needle device which comprises a needle tube provided with a piston cavity and a piston axially sliding in an inner cavity of the piston cavity, the piston is connected with a driving part extending to the outside of the needle tube, and a one-way breathable one-way valve tube is arranged on one side of the lower portion of the piston cavity. The lower end of the needle tube is sequentially connected with a pressure stabilizing tube and a buffer tube connected with the pressure stabilizing tube, a needle body is arranged at the lower end of the buffer tube, the pressure stabilizing tube comprises a tube body connected with the needle tube and the buffer tube, the upper portion and the lower portion of the tube body are respectively connected with a fixing plate provided with a plurality of air holes and a sealing block provided with a spherical adaptive through hole, and the lower portion of the fixing plate is fixedly connected with a spring. And the lower end of the spring is fixedly connected with a steel ball matched with the spherical adaptive through hole. According to the tumor tissue sampling needle, normal continuous sampling can be guaranteed, fragmented tumor tissue backflow can be effectively avoided, the total quantity of continuously obtained tumor tissue samples is guaranteed, the needle body can be effectively fixed, shaking of the needle body during continuous sampling is avoided, and safe puncture operation is guaranteed.

The invention discloses a visual bone and soft tissue tumor digging device with an ablation function, which comprises an operating handle connected with an ablation rod, and further comprises an ablation digging spoon arranged at the end of the ablation rod, an endoscope head and tissue clamping forceps arranged on the ablation rod through a clamping forceps mounting tube, the ablation digging spoon is connected with the clamping forceps installation pipe, the endoscope lens is arranged at the end of the clamping forceps installation pipe, and the endoscope lens checks the ablation process and the tissue cleaning process after ablation in real time. The microwave ablation device has the advantages that the ablation scoop with the microwave generator is designed at the front end of the ablation rod to perform microwave ablation on tumor tissue, the ablation effect is guaranteed, necrotic tissue can be removed directly by the scoop after ablation is completed, frequent replacement of medical instruments is avoided, time is saved, the tissue after ablation is removed by the telescopic tissue clamping forceps, and the ablation efficiency is improved. The tissue cleaning capacity is further improved, in the ablation and cleaning process, ablation and cleaning of tumors are observed in real time through the endoscope lens on the ablation rod, and use is convenient.

The invention provides a double-color separation probe for screening an EWSR1 gene rearrangement condition, a kit and a method thereof, relates to an EWSR1 centromere side probe carrying a first fluorophore and an EWSR1 telomere side probe carrying a second fluorophore, and judges whether an EWSR1 gene breakage condition exists or not according to a detected fluorescence signal so as to determine whether gene rearrangement exists or not. The method disclosed by the invention can be used for simply and quickly screening whether the soft tissue tumor has the EWSR1 rearrangement condition or not, and a quick and reliable basis is provided for definite diagnosis and treatment.

A pharmaceutical composition includes a microorganism-derived component. In some embodiments, the microorganism-derived component includes membrane vesicles isolated from a bacterial strain. The pharmaceutical composition can achieve the prevention and treatment of various tumors or cancers, including solid tumors, soft tissue tumors, hematologic tumors, glandular tumors, and metastatic tumors. The pharmaceutical composition demonstrates a prominent immunomodulatory or immunostimulatory effect and an intestinal regulatory function.

The invention discloses a bone soft tissue tumor auxiliary diagnosis and monitoring method for circulating tumor cell detection, which analyzes tumor evolution and progression through DNA-NGS sequencing: collecting a bone primary focus tissue sample, a blood CTC sample and a pulmonary metastatic focus tissue sample of a patient, performing DNA-NGS sequencing, comparing genome differences of the three samples, and determining the progression of the tumor. Further, tumor generation and development and cancer metastasis mechanisms are prompted; single cell transcriptome ScRNA-seq sequencing analyzes changes of immune microenvironments of bone primary lesion and pulmonary metastasis lesion, and explores CTC to realize an immune escape mechanism: comparing expression differences of bone primary lesion, blood CTC and pulmonary metastasis lesion transcriptome, and exploring effects of the immune microenvironments in a tumor metastasis process; the prognostic marker of the osteosarcoma patient is explored by dynamically monitoring the change of the CTC; the recurrence and metastasis risk of the osteosarcoma is predicted through CTC typing, namely, the difference between the CTC of the recurrent patient and the CTC of the distant metastasis patient is compared. According to the invention, the blank of CTC sequencing research of circulating tumor cells in the field of osteosarcoma lung metastasis is filled, and diagnosis and monitoring of bone soft tissue tumors are facilitated.