A suspension comprising benzimidazole carbamate and a polysorbate
A technology of benzimidazole carbamate and composition, applied in the field of suspension containing benzimidazole carbamate and polysorbate, capable of solving problems such as inability to administer drugs
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Embodiment 1
[0108] Embodiment 1 Preparation of the fenbendazole composition of the present invention
[0109] A 0.2 g / ml fenbendazole (FBZ) drinking water suspension was prepared using the following three preparation steps: a) preparation of a premixed suspension (0.4 g / ml FBZ), b) wet milling of the premixed suspension and c) dilution The suspension was premixed to give the final product (0.2 g / ml FBZ).
[0110] Formulation of the final product (0.2g / ml FBZ suspension)
[0111] substance quantity Fenbendazole 20.0g Polysorbate 80 10.0g Benzyl alcohol 2.0g Simethicone Emulsion 0.5g water Add to 100ml
[0112] A. Preparation of Premixed Suspension
[0113] Mix the required amount of simethicone emulsion and polysorbate 80 in some water using a magnetic stirrer. In order to obtain a homogeneous mixture, it was heated moderately (less than 60°C). The required amount of fenbendazole and the remaining volume of water were then added under ...
Embodiment 2
[0122] Embodiment 2 Preparation of flubendazole composition of the present invention
[0123] A 0.2 g / ml flubendazole (FluBZ) drinking water suspension was prepared using the following three preparation steps: a) preparation of a premixed suspension (0.4 g / ml FluBZ), b) wet grinding of the premixed suspension and c) dilution The premixed suspension was triturated to give the final product (0.2 g / ml FluBZ).
[0124] Formulation of the final product (0.2g / ml FluBZ suspension)
[0125] substance quantity supplier Flubendazole 20.0g Transchem Polysorbate 80 10.0g Merck Benzyl alcohol 2.0g Fluka Simethicone Emulsion 0.5g Dow Corning pure water Add to 100ml -
[0126] A. Preparation of Premixed Suspension
[0127] Mix the required amount of simethicone emulsion and polysorbate 80 in some water using a magnetic stirrer. In order to obtain a homogeneous mixture, it was heated moderately (less than 60°C). The required am...
Embodiment 3
[0142] Example 3 Alternative Wet Milling by Recirculation of Premixed Suspension - Continuous Process
[0143] First, give A 0.6 L container of MILL KDL A was filled with 450 mL of 0.25-0.3 mm glass beads (supplier B. Braun Biotech International) and then 270 mL of the premixed suspension prepared in Step A of Example 1 or 2 was added.
[0144] The milling vessel was then connected to a pump to continuously feed the mill with the premixed suspension; the flow rate was set at about 1.3 L / h. One cycle of wet milling was completed after the premixed suspension in its intact form (500 mL) was passed through the mill, separated from the milling media by a 0.1 mm gap and drained into a new container. 6 milling cycles with polyurethane discs and 4200 rpm were applied to the suspension premix.
[0145] During wet milling, the product temperature was maintained below 50°C due to heat transfer using a double cooling jacket.
[0146] The particle size of the fenbendazole suspension ...
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Abstract
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