Novel use of sodium ion channel antagonist compound in improving quality of human sleeping
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A sodium ion channel and compound technology, applied in the field of new application of sodium ion channel blocker compounds to improve human sleep quality
Inactive Publication Date: 2009-07-22
江苏宏锦天药业有限公司
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[0012] The sodium ion channel blockers referred to in the present invention have extremely strong biological activity. In the prior art, there is no reference to the amino perhydroquinazoline compounds and biguanide hydrogenated purine rings referred to in the present invention. Salts or esters of compounds and their derivatives are used to improve the sleep quality of humans or organisms
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example 1
[0147] Example 1, take tetrodotoxin (TTX), content (95-99%) 10mg, use citric acid 150μg, adjust the solution of pH=5.0-7.0 with sodium citrate, calculate by containing 10ug per 2ml, make 1000 injections Liquid, tested by HPLC, after the content is up to standard, filled, sterilized, in line with medical hygiene standards or veterinary standards, ready to use, referred to as: tetrodotoxin salt (TTX-A).
example 2
[0148] Example 2, take dehydrated tetrodotoxin, content (85-98%) 1mg, use 150μg of acetic acid, adjust the solution of PH=5.0-7.0 with sodium acetate, calculate by containing 10ug per 2ml, make 1000 injections, use PLC After testing, the content is qualified, filled, sterilized, and can be used if it meets the medical hygiene standard or veterinary standard, referred to as: tetrodotoxin C (TTX-c).
example 3
[0149] Example 3, get tetrodotoxin acid, content (85-95%) 1mg, use sodium citrate 150μg, be mixed with the solution of PH=5.0-7.0, contain 10ug calculation per 2ml, make 1000 injections, use PLC After testing, the content is qualified, filled, sterilized, and can be used if it meets the medical hygiene standard or veterinary standard. It is called tetrodotoxin f (TTX-f) for short.
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Abstract
The invention relates to novel application of sodium ion channel blocker compounds, derivatives thereof as well as pharmaceutical salts and esters of the sodium ion channel blocker compounds and the derivatives thereof in the application field of improving the sleeping quality of people and organisms, in particular to novel application that the compounds can both remarkably improve the sleeping quality of the people and the organisms when used singly and jointly used with sleeping and sedative drugs. A sodium ion channel blocker of the invention is mainly: 1, amino perhydrogenated quinazoline compounds as well as pharmaceutically salts and esters thereof; and 2, diguanidino hydrogenated purine ring compounds as well as pharmaceutically salts and esters thereof.
Description
technical field [0001] The invention relates to the application field of sodium ion channel blocker compounds and their pharmaceutically acceptable salts or esters in improving the sleep quality of humans and organisms Background technique [0002] The sodium ion channel blocker compound and pharmaceutically acceptable salts or esters thereof of the present invention refer to 1, amino perhydroquinazoline small molecule chemical compounds extracted from natural aquatic organisms represented by tetrodotoxin or artificially synthesized Element. Its molecular structural formula: [0003] [0004] Tetrodotoxin plane structure (I) Tetrodotoxin three-dimensional structure (II) [0005] Where: R 1 =R 2 =R 4 =R 5 =O H ;R 3 =CH 2 OH; tetrodotoxin, R 1 =R 3 =R 4 =R 5 =OH; R 2 =CH 2 OH; [0006] 2. Biguanide-based hydropurine ring compounds extracted from natural aquatic organisms or artificially synthesized, represented by saxitoxin. Its molecular structural formula...
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