10 results about "Ion channel blocker" patented technology

The invention relates to the technical field of biology, and particularly discloses a supercooled cell preserving fluid as well as a preserving method and application thereof. The preserving fluid is mainly prepared from RPX basic cell preserving fluid, an energy substrate, a calcium ion channel blocker, a Na < + > / H < + > exchange channel inhibitor, a colloid impermeable cell protective agent, a cell apoptosis inhibitor, an antioxidant, an inflammation inhibitor, a colloid osmotic pressure regulator, a PH regulator and the like according to a certain proportion. According to the preservation method, the cells are preserved under the subcooling condition of-1 DEG C to-7 DEG C, the cell metabolism rate is reduced to the maximum extent, meanwhile, structural and functional damage caused by freezing to the cells is eliminated, and the effect that the survival rate of the recovered cells exceeds 80% after the cells are preserved for more than 18 months under the non-freezing condition is achieved; the application opens up a way for long-term non-freezing preservation of special functional cells of cells and genetic engineering and clinical cell treatment products, provides an effective method, and lays a foundation for starting a new stage of non-freezing long-term preservation of the cells.

The present invention relates to a compound having an inhibitory effect on a plurality of sodium ion channels, or a pharmaceutically acceptable derivative thereof, a pharmaceutical composition comprising same, and a use thereof as a pan-sodium ion channel blocker.

The present invention belongs to the field of pharmaceutical chemistry. Disclosed in the present invention are a heterocyclic compound, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a series of sodium ion channel blockers having new structures, and a preparation method therefor and the use thereof. The structure thereof is as shown in the following general formula (I). These compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate or solvate thereof, or a pharmaceutically acceptable salt thereof and a pharmaceutical composition thereof can be used for treating or / and preventing related diseases mediated by a sodium ion channel (Nav).

Method for manufacturing a battery cell (202) comprising: (a) Providing a bipolar current collector (206); (b) Forming an anode coating layer (208) on a first surface of the bipolar current collector (206); (c) Forming a cathode coating layer (210) on a second surface of the bipolar current collector (206), wherein the second surface of the bipolar current collector (206) is opposite the first surface of the bipolar current collector (206); (d) Arranging a roll-to-roll ion channel blocker (214) along a first edge of the bipolar current collector (206); (e) Arranging a layer-by-layer ion channel blocker (216) along a second edge and a third edge of the bipolar current collector (206), wherein the second edge and the third edge of the bipolar current collector (206) are orthogonal to the first edge; and (f) Forming an ionically conductive gel electrolyte (218) over the anode coating layer (208) and the cathode coating layer (210), wherein the roll-to-roll ion channel blocker (214) and the layer-by-layer ion channel blocker (216) comprise a metal ion channel blocker, wherein the metal ion channel blocker comprises a non-ionically conductive gel with infinite viscosity at a shear rate of zero, wherein the non-ionically conductive gel is formed from a viscous solution comprising an organic solvent and a gelling polymer mixture comprising a crosslinkable polymer, a rheological modifier and a crosslinking initiator, and the organic solvent comprises triethyl phosphate.

The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof:The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

The invention discloses application of a calcium ion channel, an alpha 1 adrenergic receptor and an alpha 2 adrenergic receptor in treatment of premature ejaculation. The premature ejaculation can be remarkably improved by independently inhibiting calcium ion channels, alpha 1 adrenergic receptors and alpha 2 adrenergic receptors. Meanwhile, through combined application of the three target spots, premature ejaculation can be further improved. Besides, the calcium ion channel blocker and the alpha1 and alpha2 adrenergic receptor antagonists are prepared into an external preparation, so that the absorption of the medicine can be remarkably improved and the medicine effect can be quickly exerted in a smearing medication mode, and the systemic side effects of oral medication are avoided.

The present invention relates to compounds having an inhibitory effect on multiple types of sodium ion channels, or pharmaceutically acceptable derivatives thereof, and pharmaceutical compositions thereof, as well as their use as pansodium ion channel blockers.

Relates to a compound with an inhibition effect on various sodium ion channels or a pharmaceutically acceptable derivative and a pharmaceutical composition thereof, and application of the compound or the pharmaceutically acceptable derivative and the pharmaceutical composition as a sodium ion channel blocker.

The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof; The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof:The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, cough, itch, and neurogenic inflammation.