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Medicine composition for treating age-related hearing loss (ARHL) and application thereof

A technology for hearing loss and composition, applied in the field of medicine, can solve problems such as no animal model, and achieve the effect of high pharmacological activity and small side effects

Inactive Publication Date: 2012-07-04
王玉丰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the complexity of human presbycusis, so far there is no animal model that can be used as a "gold standard"

Method used

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  • Medicine composition for treating age-related hearing loss (ARHL) and application thereof
  • Medicine composition for treating age-related hearing loss (ARHL) and application thereof
  • Medicine composition for treating age-related hearing loss (ARHL) and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment Embodiment 1

[0026] Experimental Example 1: Preventive Effect of Trimethadione (TMO) on Age-Related Hearing Loss

[0027] Eight 10-month-old inbred C57BL / 6J mice in the first experimental group were used as subjects, and the auditory threshold of the mice was measured by the auditory brainstem response (ABR) method before the experiment. They were then orally given Trimethadione (TMO) through their daily drinking water for two months at a drug dose of 200 mg / kg per day. The body weight of the mice and their water intake were monitored every three days. Trimethadione solution comes in colored bottles and is changed every three days. After two months of administration, utilize auditory brainstem response (ABR) method to analyze and detect the auditory threshold value of mouse ear, assess its hearing condition, analysis result is as follows figure 1 shown. Compared figure 1 The ABR threshold shifts of the middle-dose group and the ABR threshold shift of the blank control group showed that...

experiment Embodiment 2

[0028] Experimental Example 2: Preventive effect of ebselen on age-related hearing loss

[0029] Eight 10-month-old inbred mice of the inbred line C57BL / 6J in the second experimental group were used as subjects, and the auditory threshold of the mice was determined using the auditory brainstem response (ABR) method before the experiment. They were then orally administered ebselen through their daily drinking water for two months at a dose of 400 mg / kg per day. The body weight of the mice and their water intake were monitored every three days. The ebselen solution comes in a colored bottle and is changed every three days. After two months of administration, utilize auditory brainstem response (ABR) method to analyze and detect the auditory threshold value of mouse ear, assess its hearing condition, analysis result is as follows figure 2 shown. Compared figure 2 The ABR threshold shifts of the middle administration group and the ABR threshold shifts of the blank control gr...

experiment Embodiment 3

[0030] Experimental Example 3: Preventive effect of diltiazem on age-related hearing loss

[0031]Eight 10-month-old inbred mice of the inbred line C57BL / 6J in the third experimental group were used as subjects, and the auditory threshold of the mice was determined using the auditory brainstem response (ABR) method before the experiment. They were then given orally diltiazem (diltiazem) through their daily drinking water for two months at a dose of 200 mg / kg per day. The body weight of the mice and their water intake were monitored every three days. Diltiazem solution comes in a colored bottle and is changed every three days. After two months of administration, utilize auditory brainstem response (ABR) method to analyze and detect the auditory threshold value of mouse ear, assess its hearing condition, analysis result is as follows image 3 shown. Compared image 3 The ABR threshold shifts of the middle-dose group and the ABR threshold shift of the blank control group show...

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Abstract

The invention relates to a medicine composition for treating age-related hearing loss (ARHL). The medicine composition is characterized by comprising calcium ion channel blockers and / or free radical scavengers in effective treatment dosage. According to the medicine composition, two kinds of medicine with approvals of food and drug administration (FDA), i.e. the calcium ion channel blockers and free radical scavengers (antioxidant) relevant to free radical metabolic pathways are used, the two kinds of different chemical medicines are combined to be used in a synergistic action mode, the ARHL treatment effect can be improved, and in addition, the toxic and side effect of the medicine is reduced. The innovation points of the medicine composition are mainly in the following two aspects: (1) the medicine composition is focused on 11000 kinds of medicine with FDA approvals, and the medicine has high pharmacological activity and low side effects; and (2) medicine selected in the medicine composition respectively acts on different cell-molecle mechanism target sites, and the synergistic effect can be generated after the two kinds of medicine are combined to be used.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to the prevention and treatment of hearing loss, in particular to a pharmaceutical composition and its application for treating age-related hearing loss and tinnitus caused by noise, surgery, toxins and various pressures . Background technique [0002] Age-related hearing loss (ARHL), or presbycusis, is the most common sensory loss in the elderly, mainly manifested in hearing sensitivity, speech comprehension, and sound source localization in noisy environments. Decreased capacity and reduced ability of the auditory center to process auditory information. Presbycusis affects the mood and behavior of older adults, leading to social isolation and depression. Age, noise damage, ear diseases or systemic diseases, use of ototoxic drugs, genetic susceptibility, etc. are the main causes of presbycusis (1, 2). Although all countries are trying to find various cures or palliative drugs, the ...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K45/06A61K31/554A61K31/4015A61K31/375A61K31/355A61K31/421A61K31/41A61P27/16
Inventor 王玉丰
Owner 王玉丰
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