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New use of sodium ion channel blocker in treating biology drug resistance of antibiotic

A sodium ion channel and blocker technology, which is applied in the new field of application of sodium ion channel blockers in the treatment of biological resistance to antibiotics, and can solve the problems of short life cycle and small interval of pathogenic microorganisms

Active Publication Date: 2009-06-10
江苏宏锦天药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the short life cycle of pathogenic microorganisms, the interval between generations is very small

Method used

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  • New use of sodium ion channel blocker in treating biology drug resistance of antibiotic
  • New use of sodium ion channel blocker in treating biology drug resistance of antibiotic
  • New use of sodium ion channel blocker in treating biology drug resistance of antibiotic

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0165] Example 1, take tetrodotoxin (TTX), content (95-99%) 10mg, use citric acid 150μg, adjust the solution of pH=5.0-7.0 with sodium citrate, calculate by containing 10ug per 2ml, make 1000 injections Liquid, tested by HPLC, after the content is up to standard, filled, sterilized, meet the medical hygiene standards or veterinary standards, can be used, referred to as: Tetrodotoxin Salt A.

example 2

[0166] Example 2, get deoxytetrodotoxin, content (85-98%) 1mg, use oxalic acid 150μg, adjust the solution of PH=5.0-7.0 with sodium oxalate, calculate by containing 10ug per 2ml, make 1000 injections, use PLC After the test, the content is qualified, filled and sterilized, and it can be used after meeting the medical hygiene standards or veterinary standards. It is called Tetrodotoxin B for short.

example 3

[0167] Example 3, get tetrodotoxin acid, content (85-95%) 1mg, use 150 μ g of malic acid, be mixed with the solution of PH=5.0-7.0, calculate by containing 10ug per 2ml, make 1000 injections, detect with PLC, After the content is qualified, it can be filled and sterilized, and it can be used after meeting the medical hygiene standards or veterinary standards. It is referred to as Tetrodotoxin C.

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Abstract

The invention relates to the application field for treating medicament resistance of antibiotic series medicaments for human body or biology of sodium ion channel regulating agent series compounds and medical salts and esters, especially relates to new application for treating medicament resistance of antibiotic series medicaments for human body or biology of the compounds, According to the sodium ion channel regulating agent series compounds and medical salts and esters of the invention, the medicament resistance for human body or biology generated by the antibiotic series medicaments can beeffectively treated, thereby improving the sensitivity rate and the potency of the antibiotic series medicaments for various viruses.

Description

technical field [0001] The invention relates to the field of application of sodium ion channel blocker compounds and medicinal salts and esters in the treatment of antibiotic resistance to human body or organisms Background technique [0002] The sodium ion channel blocker compounds and their pharmaceutically acceptable salts or esters described in the present invention refer to 1, amino perhydroquinazoline small molecules represented by natural aquatic organisms extracted or artificially synthesized by tetrodotoxin chemical composition. Its molecular structural formula: [0003] [0004] Tetrodotoxin plane structure (I) Tetrodotoxin three-dimensional structure (II) [0005] Where: R 1 =R 2 =R 4 =R 5 =OH,R 3 =CH 2 OH; Tetrodotoxin [0006] R 1 =R 3 =R 4 =R 5 =OH,R 2 =CH 2 OH; [0007] Tetrodotoxin molecular formula: C 11 h 17 N 3 o 8 , molecular weight 319.27. [0008] 2. Biguanide-based hydropurine ring compounds extracted from natural aquatic organi...

Claims

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Application Information

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IPC IPC(8): A61K31/529A61K31/519A61P31/00
Inventor 邱芳龙
Owner 江苏宏锦天药业有限公司
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