Application of fosfopropofol sodium in preparation of anesthetic and sedative drugs for pets
A technology of fospropofol sodium and pets, which is applied in the field of veterinary chemical drugs to achieve the effects of short half-life, reduced respiratory rate and rapid metabolism
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Embodiment 1
[0019] A preparation method of propofol sodium fat emulsion injection:
[0020] Preparation of oil phase: Measure propofol sodium and soybean oil according to the formula, add egg yolk lecithin, heat to 60°C, stir and disperse; preparation of water phase: add glycerin to an appropriate amount of water for injection, stir to dissolve Heating to 60°C; mix and stir the oil phase and water phase, add water for injection to the configured volume, the final concentration is 2.1% (w / v), pass through a two-step high-pressure homogenizer under a certain pressure, and homogenize three times to obtain The emulsion is divided into vials, sealed, and sterilized by high-pressure steam to obtain a fat emulsion.
[0021] The party list is as follows:
[0022] Formation Proportion Propofol Sodium 2.3%w / v Soybean oil 8%w / v Lecithin 2.5%w / v glycerin 5%w / v Water for Injection add up to 100%
Embodiment 2
[0024] A freeze-dried powder injection of propofol sodium: weigh propofol sodium, β-cyclodextrin, and poloxamer 188 according to the prescription, and dissolve them in a certain amount of water for injection to obtain a clear solution , adding an appropriate amount of activated carbon for injection, stirring for 20 minutes, filtering for decarburization, quantifying the filtrate with an appropriate amount of water for injection, and freeze-drying to obtain sterile powder; subpackaging, sealing, and high-pressure steam sterilization to obtain freeze-dried powder injection.
[0025] The party list is as follows:
[0026] Formation Proportion Propofol Sodium 25%w / v β-cyclodextrin 8%w / v Poloxamer 188 0.4%w / v Water for Injection Quantitative to 100%
Embodiment 3
[0027] Embodiment 3 pet cat anesthesia effect test
[0028] ECG monitors were used to continuously record heart rate, blood oxygen saturation, blood pressure, body temperature and other indicators. The test cats were selected with uniform body weight (2-5kg), and 6 healthy cats were divided into two groups, with 3 cats in each group: Adopt commercially available propofol emulsion injection and embodiment 1 propofol sodium fat emulsion injection to do clinical comparative experiment, the dosage of commercially available propofol emulsion is 5-6mg / kg, The dosage of sodium fat emulsion injection is 5-8mg / kg.
[0029] The experimental data showed that after a single intravenous injection of propofol sodium fat emulsion injection in cats for 1-2 minutes, the animals became unconscious. Before administration, the animal heart rate was 130-150 beats / min, blood oxygen saturation was 95-100, blood pressure was about 85 / 135, body temperature was 37.6-38.5°C, and respiratory rate was 30...
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