Application of fosfopropofol sodium in preparation of anesthetic and sedative drugs for pets

A technology of fospropofol sodium and pets, which is applied in the field of veterinary chemical drugs to achieve the effects of short half-life, reduced respiratory rate and rapid metabolism

Pending Publication Date: 2022-03-04
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The specific effect, metabolism, and optimal dosage of fospropofol sodium in pets, especially cats, in clinical surgical anesthesia have not yet been reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A preparation method of propofol sodium fat emulsion injection:

[0020] Preparation of oil phase: Measure propofol sodium and soybean oil according to the formula, add egg yolk lecithin, heat to 60°C, stir and disperse; preparation of water phase: add glycerin to an appropriate amount of water for injection, stir to dissolve Heating to 60°C; mix and stir the oil phase and water phase, add water for injection to the configured volume, the final concentration is 2.1% (w / v), pass through a two-step high-pressure homogenizer under a certain pressure, and homogenize three times to obtain The emulsion is divided into vials, sealed, and sterilized by high-pressure steam to obtain a fat emulsion.

[0021] The party list is as follows:

[0022] Formation Proportion Propofol Sodium 2.3%w / v Soybean oil 8%w / v Lecithin 2.5%w / v glycerin 5%w / v Water for Injection add up to 100%

Embodiment 2

[0024] A freeze-dried powder injection of propofol sodium: weigh propofol sodium, β-cyclodextrin, and poloxamer 188 according to the prescription, and dissolve them in a certain amount of water for injection to obtain a clear solution , adding an appropriate amount of activated carbon for injection, stirring for 20 minutes, filtering for decarburization, quantifying the filtrate with an appropriate amount of water for injection, and freeze-drying to obtain sterile powder; subpackaging, sealing, and high-pressure steam sterilization to obtain freeze-dried powder injection.

[0025] The party list is as follows:

[0026] Formation Proportion Propofol Sodium 25%w / v β-cyclodextrin 8%w / v Poloxamer 188 0.4%w / v Water for Injection Quantitative to 100%

Embodiment 3

[0027] Embodiment 3 pet cat anesthesia effect test

[0028] ECG monitors were used to continuously record heart rate, blood oxygen saturation, blood pressure, body temperature and other indicators. The test cats were selected with uniform body weight (2-5kg), and 6 healthy cats were divided into two groups, with 3 cats in each group: Adopt commercially available propofol emulsion injection and embodiment 1 propofol sodium fat emulsion injection to do clinical comparative experiment, the dosage of commercially available propofol emulsion is 5-6mg / kg, The dosage of sodium fat emulsion injection is 5-8mg / kg.

[0029] The experimental data showed that after a single intravenous injection of propofol sodium fat emulsion injection in cats for 1-2 minutes, the animals became unconscious. Before administration, the animal heart rate was 130-150 beats / min, blood oxygen saturation was 95-100, blood pressure was about 85 / 135, body temperature was 37.6-38.5°C, and respiratory rate was 30...

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PUM

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Abstract

The invention discloses application of fosfopropofol sodium in preparation of a pet anesthesia, sedation and hypnosis medicine preparation, and belongs to the field of chemical medicine preparations, the medicine preparation is a fosfopropofol sodium freeze-dried powder injection or a fosfopropofol sodium injection, and is delivered through injection; the pharmaceutical preparation comprises fosfopropofol sodium and one or more than one pharmaceutic adjuvant. The fosfopropofol sodium pharmaceutical preparation disclosed by the invention is used for pet operation anesthesia, especially cat anesthesia, and is outstanding in sedation effect and relatively good in bioavailability.

Description

technical field [0001] The invention belongs to the technical field of veterinary chemical drugs, and in particular relates to the application of fospropofol sodium in the preparation of pet anesthesia and sedative drugs. Background technique [0002] Propofol is widely used clinically. It is a clinically mature intravenous anesthetic widely used in the induction and maintenance of general anesthesia. It has the advantages of quick onset and easy recovery. However, propofol injection is painful, reduces systolic blood pressure, diastolic blood pressure and mean arterial blood pressure, leading to clinically induced hypotension, and respiratory depression is also a non-negligible risk of propofol. Therefore, propofol has great disadvantages in the clinical application of cardiovascular, brain injury and chronic hypotension. [0003] Fospropofol sodium (Fospropofol disodium), the chemical name is 2,6-diisopropylphenoxymethyl phosphate disodium, fospropofol sodium is a water-s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/661A61P23/00A61P25/20
CPCA61K31/661A61P23/00A61P25/20
Inventor 刘爱玲李亚玲梁莉张玉良郝小妹吴燕子李守军
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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