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Traditional Chinese medicine composition for improving sleep and preparation method and use thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition for improving sleep and its preparation, can solve problems such as difficult drug withdrawal and obvious side effects, and achieve the effects of prolonging sleep time, increasing sedation rate, and inhibiting the distance of autonomous activities

Pending Publication Date: 2022-01-04
JIANGHAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Currently, the most widely used drugs for the treatment of insomnia are benzodiazepines, which are clinically proven to be effective, but also have significant side effects. Long-term use of such sleeping pills may lead to a certain degree of dependence and make withdrawal difficult

Method used

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  • Traditional Chinese medicine composition for improving sleep and preparation method and use thereof
  • Traditional Chinese medicine composition for improving sleep and preparation method and use thereof
  • Traditional Chinese medicine composition for improving sleep and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 single-component and compound composition comparison

[0024] 1. Experimental animals: clean grade male Kunming mice, weighing 18-22g. They were raised in a well-ventilated animal laboratory with 12h / 12h alternation of light and dark, ambient temperature (22±2)°C, and relative humidity (55±5)%. Sufficient feed and free drinking water were used after 7 days of adaptation to the environment.

[0025] 2. Drugs and reagents:

[0026] Single component: respectively Huangteng group, Ligusticum group, Haifengteng group, Plantago group and Aster group;

[0027] The compound composition: it includes yellow teng, fenugreek, sea wind vine, plantain seed and aster with a mass ratio of 1:2:4:2:2.

[0028] The preparation method is as follows: (1) Take the vine stems of the yellow vine, wash them, cut them into sections, dry them in the sun and grind them into powder, finely sieve them with a filter (No. 2 sieve) to remove impurities, and then dry them naturally at 28...

Embodiment 2

[0074] The proportioning of embodiment 2 compound composition is explored

[0075] In order to explore the optimal proportioning ratio of the compound Chinese medicine composition, each component is mixed in different proportions, and the specific grouping is as follows:

[0076] Compound composition A: including Huangteng, Liga, Haifengteng, Plantago and Aster with a mass ratio of 0.5:1:2:1:1;

[0077] Compound composition B: including Huangteng, Liga, Haifengteng, Plantago and Aster with a mass ratio of 1:2:4:2:2;

[0078] Compound composition C: comprising Huangteng, Liga, Caulis, Semen Plantaginis and Aster with a mass ratio of 2:3:6:3:3.

[0079] The above three groups of compound compositions were used to carry out the mouse autonomous activity test, the direct sleep test, the effect experiment on the number of mice falling asleep with a subthreshold dose of pentobarbital sodium, and the effect on the sleep latency of the suprathreshold dose of pentobarbital sodium mice...

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Abstract

The invention discloses a traditional Chinese medicine composition for improving sleep and a preparation method and use thereof. The traditional Chinese medicine composition is prepared from herba fibraureae recisae, thlaspi arvense, kadsura pepper stem, semen plantaginis and radix asteris at a mass ratio of (0.5-2):(1-3):(2-6):(1-3):(1-3). The traditional Chinese medicine composition is prepared from the multiple traditional Chinese medicine components. A mixing proportion and a use dosage of the traditional Chinese medicine components are explored, and the corresponding traditional Chinese medicine composition is prepared. A research finds that compared with a single formula, the traditional Chinese medicine composition can remarkably inhibit an autonomous activity distance of mice and increase a sedative rate through a synergistic effect of the components, such that the traditional Chinese medicine composition can be prepared into sedative drugs. Meanwhile, the traditional Chinese medicine composition and a subthreshold or suprathreshold dose of pentobarbital sodium jointly act on the mice, can effectively increase a sleep rate of the mice, shorten a sleep latency period and remarkably prolong sleep time. Therefore, the traditional Chinese medicine composition has an effect of improving sleep and provides an experimental basis for development and utilization of drugs for treating insomnia.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for improving sleep, a preparation method and application thereof. Background technique [0002] Sleep is an indispensable physiological phenomenon for human beings. In a person's life, sleep accounts for nearly 1 / 3 of the time, and its quality is closely related to the health of the human body. This shows how important sleep is to everyone. Long-term insomnia will have a significant impact on the quality of life, functional ability and health status of patients. Poor sleep and insomnia can make people inattentive and seriously affect daily life and work. People with long-term insomnia will increase the risk of diseases such as high blood pressure and depression. disease risk. [0003] Currently, the most widely used drugs for the treatment of insomnia are benzodiazepines, which are clinically proven to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/68A61K31/515A61P25/20
CPCA61K36/59A61K36/31A61K36/67A61K36/68A61K36/28A61K31/515A61P25/20A61K2300/00
Inventor 李长雷马宝苗易卉玲陈晓青熊哲
Owner JIANGHAN UNIVERSITY
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