Application of combination of lamivudine and domperidone in preparation of sedative drug

Abstract

The invention provides an application of a combination of lamivudine and domperidone in preparation of a sedative drug. A study finds that the lamivudine and the domperidone can play an exact sedationrole when combined at a specific ratio; and furthermore, the lamivudine and the domperidone are relatively mild in sedation effect and do not cause a communication loss or difficulty in wake-up. A further pharmacological property study shows that the drug can promote binding of a GABA receptor and a GABAA receptor, so that the opening frequency of a chloride ion channel is increased; meanwhile, the content of glutamic acid in cerebral cortex and hypothalamus of an experimental animal is lowered, so as to reduce excitatory neurotoxicity in the brain; and furthermore, the drug can be selectively combined with a 5-hydroxytryptamine 1A receptor and inhibits uptaking of 5-hydroxytryptamine by cynapse, so as to increase the content of the 5-hydroxytryptamine. Based on the discovered new properties, a new application of the combination of the lamivudine and the domperidone the in preparation of the sedative drug is determined, so that the optional range of the sedative drug is expanded and the sedation effect is improved to a certain extent.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, and further relates to the new medical application of substances, in particular to the application of lamivudine and domperidone in combination for the preparation of sedative drugs. Background technique [0002] Sedatives are a general term for a large class of drugs that promote calmness and sleep in the human body. They are mainly used for the symptomatic treatment of symptoms such as mental disorders, anxiety and irritability. Ideal sedative drugs need to have the following characteristics: 1. Little impact on circulation and breathing: 2. The effect is fast and the effect is obvious; 3. The drug is metabolized quickly and basically has no obvious accumulation effect; 4. It has little effect on liver and kidney functions; 5. It has excellent anti-anxiety and compliant amnesia effects, and it is easy to wake up when using it. At present, the commonly used sedatives mainly include b...

AI Technical Summary

Problems solved by technology

In the prior art, no lamivudine or domperidone has been found to have a sedative effect or a central nervous system inhibitory effect on the human body

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