Sulfhydryl imidazopyridine derivative containing dioxepane-pyridine

Abstract

The invention belongs to the pharmaceutical technical field and specifically relates to sulfhydryl imidazopyridine derivatives which are shown in general formula (I) and contain diosulberane pyridine, isomers and pharmaceutically acceptable salts thereof, wherein, R<1>, R<2> and R<3> are defined as in the specification. The invention also relates to preparation methods of the compounds, drug compositions containing the compounds and the application of the compounds in preparing drugs for preventing and / or treating digestive ulcer.

Description

1. Technical field The invention belongs to the technical field of medicine, and in particular relates to mercaptoimidazopyridine derivatives containing dioxepanepyridine, its isomers and pharmaceutically acceptable salts thereof, preparation methods of these compounds, and medicines containing these compounds Compositions, and the application of these compounds in the preparation of medicines for treating and / or preventing peptic ulcer. 2. Background technology Diseases of the digestive system are one of common frequently-occurring diseases, and the incidence of ulcer disease accounts for about 10% to 12% of the total population. The initial treatment is mainly to use antacids (such as sodium bicarbonate, aluminum hydroxide, etc.) to neutralize gastric acid to relieve symptoms. After the 1970s, with the H 2 The discovery of gastric acid secretion inhibitors such as receptor blockers and proton pump inhibitors has created a new era of peptic ulcer treatment. These drugs ha...

AI Technical Summary

Problems solved by technology

However, the onset time of these drugs is slow, and the drug effect is not strong enough. It takes several doses (that is, a few days) to achieve the maximum acid-suppressing effect, and it may not be able to stably suppress acid for 24 hours. The time of taking the drug and eating may affect the effect of the drug. Pharmacokinetic parameters, individual differences in pharmacokinetics, and significant interactions with other drugs

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