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Combination therapy

A technology of inhibitors and agonists, used in the field of therapeutics and medical chemistry, can solve the problem that chemotherapy or radiation therapy of leukemia is not so effective

Inactive Publication Date: 2009-08-05
GENZYME CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Specifically, chemotherapy or radiation therapy for leukemia may be less effective if the leukemic or pre-leukemic cells are maintained or attracted to the bone marrow rather than the circulatory system, which is more sensitive to treatment

Method used

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Examples

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Embodiment 1

[0082] transfer progenitor cells

[0083] Mice were treated with recombinant human granulocyte-colony stimulating factor (G-CSF) at a dose of 50 μg / kg subcutaneously twice daily for 4 days (total dose 100 μg / kg / day / mouse). Sixteen hours after the last dose of G-CSF, mice were simultaneously injected with recombinant human GROβ at a dose of 2.5 mg / kg and AMD3100 at a dose of 5.0 mg / kg. Peripheral blood of mice was collected 15 minutes after administration of GROβ and AMD3100 to quantify metastasis. Each injection was preplanned so that control and transferred mice could be evaluated simultaneously in each experiment. CO 2Mice were sacrificed by asphyxiation, and blood was obtained by cardiac puncture using an EDTA (ethylenediaminetetraacetic acid)-coated syringe. PBMC were obtained by separating peripheral blood (0.4 mL) using Lympholyte-M from Cedarlane Labs, Hornby, ON, Canada. Complete blood counts (CBC) were performed with a Hemavet Mascot from CDC Technologies, Oxfor...

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Abstract

Methods to mobilize progenitor and / or stem cells from the bone marrow to the bloodstream by administering a combination of at least one CXCR4 inhibitor, at least one CXCR2 agonist, and G-CSF are described. The combinations may also be used to increase the effectiveness of chemotherapy and radiation therapies for hematopoietic malignancies.

Description

[0001] related application [0002] This application claims priority to US Provisional Application Serial No. 60 / 836,409, filed August 7, 2006, which is hereby incorporated by reference in its entirety. technical field [0003] This invention is in the field of therapeutic and medicinal chemistry. More specifically, the present invention relates to methods of rapidly mobilizing progenitor / stem cells, including precancerous progenitor cells and / or stem cells, into the bloodstream using combination therapy. Background technique [0004] Peripheral blood stem cell transplantation (PBSCT) is a new technique to obtain progenitor and / or stem cells from a patient's blood and use them to restore the immune system of patients undergoing chemotherapy and / or radiation therapy (including, in some cases, blood donors). In order to obtain stem cells, these cells must be transferred or engrafted into the peripheral blood. The strongest marker of this transplant success (determined by th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/02A61K38/18A61K38/19C07K14/475C07K14/52C12P21/00
CPCA61K31/00A61K38/19A61K31/395A61K38/195A61K38/193A61P35/00A61P35/02A61P35/04A61P43/00A61K2300/00
Inventor G·布里杰L·M·佩鲁斯
Owner GENZYME CORP
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