Pressurised metered dose inhalers containing solutions of beta-2 agonists
A pressurized metered dose inhalation and preparation technology, which can be used in medical preparations containing active ingredients, medical preparations without active ingredients, and liquid delivery, etc., and can solve problems such as no therapeutic effect.
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Embodiment 1
[0092] Example 1 - Ultrafine TA 2005HFA formulation
[0093] A formulation delivering a nominal dose of 1 μg of active ingredient per actuation was prepared with the following composition:
[0094]
[0095] * Equivalent to 2.0μl
[0096] The formulation (120 actuations / jar over 30 actuations) was filled into aluminum cans coated with Teflon on the inner surface (two-stage pressure filling) and equipped with a metering valve with a 63 μl metering chamber. An actuator with a bore diameter of 0.22mm is used. Results were obtained as the average of 2 pots.
[0097] Similarly, formulations may be prepared to deliver nominal doses of 2, 3 or 4 [mu]g of active ingredient per actuation. The aerodynamic particle size distribution was determined by ACI according to page 16, lines 10-18, and the delivery characteristics of each formulation were determined according to the following parameters: i) nominal dose: theoretical dose for a single actuation; ii) delivered dose: Amount of ...
Embodiment 2
[0102] Example 2 - Ultrafine HFA formulation containing TA 2005 and 22R-budesonide
[0103] A formulation delivering a nominal dose of 1 μg of TA 2005 and 80 μg of 22R-budesonide per actuation was prepared with the following composition:
[0104]
[0105] * Equivalent to 3.3 μl
[0106] The formulation (120 actuations / jar, over 30 actuations) was filled into aluminum cans coated with Teflon on the inner surface (two-stage pressure filling) and equipped with a metering valve with a 63 μl metering chamber.
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