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Compositions comprising calcium citrate malate and methods for making the same

A technology of calcium malate and citric acid, which is applied to medical preparations containing active ingredients, active ingredients of anhydride/acid/halide, pharmaceutical formulations, etc. Reduce customer satisfaction and other issues

Inactive Publication Date: 2011-11-16
PROCTER & GAMBLE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Additionally, currently available calcium citrate malate powders often do not dissolve completely, forming undesirable clumps that are not acceptable to consumers
Additionally, many currently available powders can adversely affect the taste and / or texture of the food or beverage to which they are added, further reducing consumer satisfaction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0053] Upon completion of preparation of the calcium citrate malate mixture, the calcium citrate malate mixture may have a calcium concentration of from about 4% to about 9% by weight of the calcium citrate malate mixture, and in one embodiment has a calcium concentration of about 4.5% to about 8%, and in another embodiment has a calcium concentration of about 5% to about 6.5%.

[0054] A calcium source, a source of citrate, a source of malate and water are combined to make a calcium citrate-malate mixture which reacts a source of calcium with a source of citrate and a source of malate. One type of reaction that can occur is the neutralization reaction between the alkaline calcium source and the acid forms of citrate and malate. Other reactions that can occur are coordination reactions between dissolved calcium ions and citrate and malate ions, which can form various soluble complexes.

[0055] After the calcium source is mixed with the citrate source and the malate source to...

Embodiment 1

[0133] In a 1-liter glass beaker, dissolve approximately 73.04 g of citric acid and approximately 76.16 g of malic acid in approximately 258 mL of distilled deionized water and stir using a Teflon-coated magnetic stir bar for approximately 5 minutes, or until acid The solution was clear. The beaker was immersed in a non-circulating water bath at 25°C.

[0134] In a 500 mL glass beaker, about 84 g of calcium hydroxide was dispersed in about 250 mL of distilled deionized water while stirring to generate a calcium hydroxide slurry. The calcium hydroxide slurry was then rapidly added to the acid solution to produce a calcium citrate malate mixture. Rinse the calcium hydroxide beaker with about 60 mL of deionized water and add to the calcium citrate malate mixture. The temperature of the calcium citrate malate mixture rose to about 64.8°C and the temperature was above about 60°C for less than about 60 seconds. The mixture was then cooled to about 33°C in a water bath over about ...

Embodiment 2

[0137] In a 1-liter glass beaker, dissolve about 73.04 g of citric acid and about 76.16 g of malic acid in about 228 mL of distilled deionized water and stir using a Teflon-coated magnetic stir bar for about 5 minutes, or until acid The solution was clear. The beaker was immersed in a non-circulating water bath at about 25°C. In a 500 mL glass beaker, about 84 g of calcium hydroxide was dispersed in about 260 mL of distilled deionized water while stirring to generate a calcium hydroxide slurry. The calcium hydroxide slurry was then rapidly added to the acid solution to produce a calcium citrate malate mixture. Rinse the calcium hydroxide beaker with approximately 100 mL of deionized water and add to the calcium citrate malate mixture. The temperature of the calcium citrate malate mixture rose to about 61°C and the temperature was above about 60°C for less than about 10 seconds. The mixture was then cooled to about 33°C in a water bath over about 15 minutes to obtain a calci...

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PUM

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Abstract

A process for producing a calcium citrate malate composition by the steps of: combining a calcium source, a citrate source, a malate source and water to form a calcium citrate malate mixture. The mixture is reacted until reaching a peak temperature of from about 45 DEG C to about 700C, and then cooled at a rate of from about l DEG C / minute to about 4 DEG C / minute to reach a final temperature of less than about 400C. A calcium citrate malate precipitate is formed and then dried to obtain the calcium citrate malate composition.

Description

field of invention [0001] Embodiments of the present invention generally relate to compositions comprising calcium citrate malate and methods for their preparation. Background of the invention [0002] Calcium is a mineral that helps build and maintain strong bones and prevents bone diseases such as osteoporosis. Therefore, it is important for the individual to consume a diet rich in calcium. Although a variety of dairy products provide good sources of calcium, many individuals find it difficult to obtain the calcium they need. One reason for this problem is that many individuals often find that the amount of these foods consumed is insufficient to meet their recommended daily calcium requirement. With milk in particular, many individuals enjoy an occasional glass of milk, but may find it challenging that they need to consume approximately three full glasses to meet their recommended daily intake of calcium. This task is even more difficult if the individual suffers from ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/19A61K33/06
CPCA61K31/19A61K33/06C07C59/265A61K9/1688A61K31/194C07C59/245
Inventor A·P·鲁哈迪亚T·W·达克G·R·胡德珀尔D·B·康普顿
Owner PROCTER & GAMBLE CO
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