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Thiolated macromolecules and methods of making and using thereof

A technology of macromolecules and thiols, which is applied in the field of thiolated macromolecules and their preparation and application, and can solve the problem that macromolecules are not cross-linked quickly

Inactive Publication Date: 2009-08-19
UNIV OF UTAH RES FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The macromolecules are not rapidly crosslinked by previously used chemical crosslinking techniques

Method used

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  • Thiolated macromolecules and methods of making and using thereof
  • Thiolated macromolecules and methods of making and using thereof
  • Thiolated macromolecules and methods of making and using thereof

Examples

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Embodiment

[0179] The following examples are presented to provide those of ordinary skill in the art with a complete disclosure and description of how to make and evaluate the compounds, compositions and methods described and claimed herein, and are purely illustrative purpose, and not for the purpose of limiting the scope of what the inventors regard as their invention. Efforts have been made to ensure accuracy with respect to numbers (eg, amounts, temperature, etc.), but some errors and deviations should be accounted for. Unless indicated otherwise, parts are parts by weight, temperature is in degrees Celsius (° C.) or is at ambient temperature, and pressure is at or near atmospheric. There are numerous variations and combinations of reaction conditions such as: component concentrations, desired solvents, solvent mixtures, temperatures, pressures, and other reactions that can be used to optimize the purity and yield of products obtained from the described methods scope and conditions....

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Abstract

Described herein are thiolated macromolecules and methods of making and using thereof.

Description

Background technique [0001] Arthritis generally refers to a diseased condition that causes pain and inflammation in over a hundred joints. The two most common diseases attributable to the above symptoms are osteoarthritis (OA) and rheumatoid arthritis (RA). Osteoarthritis (OA), also known as osteoarthritis, is caused by the wear and tear of joints and affects more than 20 million Americans. Osteoarthritis (OA) particularly affects weight-bearing synovial joints. In contrast, rheumatoid arthritis (RA) is an autoimmune disease that causes inflammation and ultimately the destruction of cartilage as well as bone. Anatomically, the synovial joint is characterized by the synovium, cartilage, subchondral bone, synovial fluid, and joint capsule. In arthritis, the cartilage of the joints slowly degrades and eventually disappears. However, changes also occur within the subchondral bone, joint capsule, and the synovial fluid. High molecular weight hyaluronic acid (HA) is the main sy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00C08B37/04C08B37/06C08B37/08C08B37/10C08H1/00C08H1/06C12N5/00A61K47/36A61K31/715A61K31/726A61K31/728A61L27/20
CPCC08H1/00C08B37/003A61K31/728C08B15/00A61K45/06C08B37/0075A61L31/042C08B11/04C08B15/005C08B37/0045A61L27/20C08B37/0072C08B11/20C08B37/00C08H1/06C08B37/0063C08B37/0084C08B37/0069A61P17/02A61P41/00C08L5/08
Inventor G·D·普雷斯特维奇M·谢尔班
Owner UNIV OF UTAH RES FOUND