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Biofluid metabolite profiling as a tool for early prediction of autoimmunity and type 1 diabetes risk

A technology for type 1 diabetes and metabolites, which is applied in the fields of biomaterial analysis, metabolic diseases, and analytical materials, and can solve problems that hinder the evaluation of absolute disease risk and disease onset time, and the discovery of effective prevention

Inactive Publication Date: 2009-09-09
ZORA BIOSCIENCES OY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unknown triggers of autoimmunity and lack of understanding of mechanisms supporting β-cell failure not only hinder assessment of absolute disease risk and time to disease onset in genetically susceptible individuals, but also impede discovery of effective prevention

Method used

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  • Biofluid metabolite profiling as a tool for early prediction of autoimmunity and type 1 diabetes risk
  • Biofluid metabolite profiling as a tool for early prediction of autoimmunity and type 1 diabetes risk
  • Biofluid metabolite profiling as a tool for early prediction of autoimmunity and type 1 diabetes risk

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Embodiment approach

[0030] The serum metabolites to be used as biomarkers are preferably metabolites that protect against oxidative stress and / or inflammation. In this case, a reduced concentration thereof in the child to be diagnosed compared to a control group of healthy children is indicative of the child's susceptibility to developing type 1 diabetes.

[0031] The expression "reduced concentration" is understood to mean that the level of a biomarker in children belonging to the risk group may be at most 80% of the level of the same biomarker in healthy controls. However, the level in the risk group will generally be at most 75% of the control level, more usually at most 65% to at most 50%.

[0032] In a preferred embodiment, the biomarker is total phospholipids, one or more ester-linked phosphorylcholines or total ester-linked phosphorylcholines. In all these approaches, the biomarkers are preferably already determined in the newborn, for example by cord blood analysis. In a particularly pr...

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Abstract

The invention concerns a method for diagnosing a child's susceptibility for developing type 1 diabetes by using a serum metabolite as biomarker. The invention concerns also a method for prevention of the onset of type 1 diabetes in a child.

Description

technical field [0001] The present invention relates to a method for the early diagnosis of a child's susceptibility to developing type 1 diabetes. Furthermore, the present invention also relates to a method for preventing type 1 diabetes in children diagnosed as prone to developing type 1 diabetes. Background technique [0002] The publications and other materials used herein to illustrate the background of the invention, particularly the Examples which provide additional details about the practice, are hereby incorporated by reference. [0003] Type 1 diabetes is an autoimmune disease in which the body's own immune system attacks the beta cells in the islets of the pancreas, destroying them or damaging them enough to reduce or eliminate insulin production. [0004] In almost all Western countries, the incidence of type 1 diabetes (the most common childhood metabolic-endocrine disease) has increased for unknown reasons during the past 10-50 years. The development of β-cel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50G01N33/92
CPCG01N33/92G01N2800/042G01N33/38G01N2405/04G01N33/6893A61P3/10Y10T436/203332
Inventor 马泰·奥伦西克奥利·西梅尔图利基·塞佩宁-拉克索马尔科·西西-阿霍
Owner ZORA BIOSCIENCES OY
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