Ginsenoside Rg 3 and phospholipid complex and preparing method thereof

A technology of phospholipid complexes and ginsenosides, which is applied in drug delivery, drug combination, and pharmaceutical formulations, etc., can solve the problems of not having fat solubility, and achieve the effect of improving fat solubility, improving solubility, and easy absorption

Active Publication Date: 2009-09-16
SHENYANG WANJIA INST OF BIOLOGICAL TECH RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Chinese patent discloses the preparation method of hydroxypropyl cyclodextrin of ginsenoside Rg3, which improves the water solubility of ginsenoside Rg3, but does not have fat solubility

Method used

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  • Ginsenoside Rg 3 and phospholipid complex and preparing method thereof
  • Ginsenoside Rg 3 and phospholipid complex and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 20(R)—Ginsenoside Rg 3 50mg, add ethyl acetate 200ml, add soybean lecithin 100mg (ginsenoside Rg3 50mg: phospholipid 100mg is equivalent to molar ratio 1:2), heat to 80 ℃ reflux and stir for 2 hours, remove the reaction solvent ethyl acetate under reduced pressure, routine Drying in vacuum at low temperature gives a colorless semi-solid compound-ginsenoside Rg3 phospholipid complex.

Embodiment 2

[0027] Take 20(S)—Ginsenoside Rg 3 100mg, add 500ml of tetrahydrofuran, add 200mg of soybean lecithin, heat to 50°C and reflux, shake and react for 4 hours, remove the reaction solvent tetrahydrofuran under reduced pressure, and dry in vacuum at low temperature to obtain a colorless semi-solid complex - ginsenoside Rg3 phospholipid complex.

Embodiment 3

[0029] Take 3100mg of ginsenoside Rg, add 200ml of acetone, add 100mg of egg yolk phospholipid, heat to reflux at 60°C, stir and react for 1 hour, remove the reaction solvent acetone under reduced pressure, add n-hexane to dissolve, filter, recover the solvent n-hexane from the filtrate under reduced pressure, and vacuum the residue at low temperature Dried to obtain fine ginsenoside Rg3 phospholipid.

[0030] Described acetone can be replaced by ethanol, butanol or ether.

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Abstract

The invention discloses a ginsenoside Rg 3 and phospholipid complex and a preparing method thereof, belonging to the filed of medicines and health care products. The components comprise ginsenoside Rg 3 and phospholipid, and the mol ratio of the ginsenoside Rg 3 to the phospholipid is 1 : 1 to 10. The preparing method adopts organic solvent with small dielectric constant to dissolve the mixture of the ginsenoside Rg 3 and the phospholipid, and then the ginsenoside Rg 3 and phospholipid complex is prepared after the technical processes of solvent evaporation and the like. The ginsenoside Rg 3 and phospholipid complex has fat solubility and high bioavailability, and can be easily absorbed by human bodies and made into preparations such as emulsion and the like.

Description

technical field [0001] The invention relates to a ginsenoside Rg3 phospholipid complex, a preparation method and a preparation thereof, and belongs to the field of medicine and health products. Background technique [0002] Ginsenoside Rg3 is a tetracyclic triterpenoid saponin compound extracted and isolated from the Chinese herbal medicine ginseng, and its molecular formula is C 42 h 72 o 13 , the molecular weight is 784.13. Due to the difference in the spatial position of the 20-hydroxyl group, there are two enantiomers, 20-(R) and 20-(S). The structural formula of ginsenoside Rg3 is as follows: [0003] [0004] Ginsenoside Rg3 has various biological activities such as anti-tumor and immune regulation, improving microcirculation, regulating digestive system skills, calming the nerves, anti-aging, anti-stress, preventing digestive ulcers, improving quality of life, enhancing memory and learning ability. Ginsenoside Rg3 has a clear curative effect, but its water sol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/704A61K9/00A61P35/00A61P37/02A61P9/00A61P1/00A61P25/00
Inventor 穆英俊董英杰艾莉李昊天
Owner SHENYANG WANJIA INST OF BIOLOGICAL TECH RES
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